Ketanserin

Also known as: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione, R41468, Taseron, Sufrexal, Serepress, Serefrex, Ketensin, Perketan, R 41,468, MFCD00083392, EINECS 277-680-2

Ketanserin (CAS 74050-98-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H22FN3O3 and a molecular weight of 395.427 g/mol. Key properties include a melting point of 227-235°C and a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 74050-98-9
Jingsj CID: J-42435-1
Molecular Formula: C₂₂H₂₂FN₃O₃
Molecular Weight: 395.427 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	227-235°C
Density	1.3±0.1 g/cm3
Exact Mass	395.164520
PSA	75.17000
LogP	3.21
Refractive Index	1.593
Storage Conditions	2-8°C
Additional Property	DMF: 10 mg/mL, clear, colorless

Activity & Biological Data

Target	IC50: 0.11 μM (hERG current)[1] IC50: 152±23 μM (5-HT receptor)[2]
Additional Information	[1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73. [2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506. [3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76. [4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.

Target

IC50: 0.11 μM (hERG current)[1] IC50: 152±23 μM (5-HT receptor)[2]

Additional Information

[1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73. [2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506. [3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76. [4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ketanserin?

The CAS number of Ketanserin is 74050-98-9.

What are the molecular formula and molecular weight of Ketanserin?

Ketanserin has molecular formula C22H22FN3O3 and molecular weight 395.427 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ketanserin (CAS 74050-98-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42435-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.