Spironolactone

Also known as: Aldactone, SC9420, Osyrol, Spirolactone, Dira, Altex, Acelat, Aldace, Osiren, Lacalmin, Lacdene, Laractone, Nefurofan, Sagisal, Sincomen, Spiretic, Spiroderm, Spirolone, Supra-puren, Suracton

Spironolactone (CAS 52-01-7) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C24H32O4S and a molecular weight of 416.573 g/mol. Key properties include a melting point of 207-208 °C(lit.), a boiling point of 597.0±50.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 302.3±18.1 °C. It is classified under GHS with signal word Danger and hazard statements H360 — May damage fertility or the unborn child. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 52-01-7
Jingsj CID: J-42127-6
Molecular Formula: C₂₄H₃₂O₄S
Molecular Weight: 416.573 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	207-208 °C(lit.)
Boiling Point	597.0±50.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	302.3±18.1 °C
Exact Mass	416.202118
PSA	85.74000
LogP	3.12
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.586
Additional Property	practically insoluble

GHS Safety & Compliance

Health HazardSignal word: Danger

H360 — May damage fertility or the unborn child

Activity & Biological Data

Additional Information	[1]. Berardesca, E., et al., Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris. Int J Tissue React, 1988. 10(2): p. 115-9. [2]. Pitt, B., et al., The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med, 1999. 341(10): p. 709-17.

Additional Information

[1]. Berardesca, E., et al., Topical spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris. Int J Tissue React, 1988. 10(2): p. 115-9. [2]. Pitt, B., et al., The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med, 1999. 341(10): p. 709-17.

Customs & Trade Information

HS Code	2937290090

Frequently Asked Questions

What is the CAS number of Spironolactone?

The CAS number of Spironolactone is 52-01-7.

What are the molecular formula and molecular weight of Spironolactone?

Spironolactone has molecular formula C24H32O4S and molecular weight 416.573 g/mol.

Is Spironolactone hazardous?

Spironolactone has GHS signal word Danger and hazard statements H360 — May damage fertility or the unborn child.

What are the upstream and downstream products of Spironolactone?

For Spironolactone, Upstream Products: Canrenone, Thioacetic acid, Ethisterone; Downstream Products: Canrenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Spironolactone (CAS 52-01-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42127-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.