Paliperidone

Also known as: 9-Hydroxyrisperidone, Risperidone EP Impurity C, 9-OH-risperidone, Risperidone Impurity 3, Racemic Paliperidone, Invega

Paliperidone (CAS 144598-75-4) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C23H27FN4O3 and a molecular weight of 426.484 g/mol. Key properties include a melting point of 158-160°C, a boiling point of 612.3±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 324.1±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 144598-75-4
Jingsj CID: J-42125-0
Molecular Formula: C₂₃H₂₇FN₄O₃
Molecular Weight: 426.484 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	158-160°C
Boiling Point	612.3±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	324.1±34.3 °C
Exact Mass	426.206726
PSA	84.39000
LogP	1.52
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.692
Storage Conditions	Room temp

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147(1):14-23. [2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410. [3]. Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12(3):425-31.

Additional Information

[1]. Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147(1):14-23. [2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410. [3]. Kalman S, et al. 9-hydroxy-risperidone (9OHRIS) prevents stress-induced β-actin overexpression in rat hippocampus. Neuropsychopharmacol Hung. 2010 Sep;12(3):425-31.

Frequently Asked Questions

What is the CAS number of Paliperidone?

The CAS number of Paliperidone is 144598-75-4.

What are the molecular formula and molecular weight of Paliperidone?

Paliperidone has molecular formula C23H27FN4O3 and molecular weight 426.484 g/mol.

Is Paliperidone hazardous?

Paliperidone has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Paliperidone?

For Paliperidone, Upstream Products: Paliperidone Palmitate, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole; Downstream Products: 9-Keto Risperidone, Paliperidone Palmitate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Paliperidone (CAS 144598-75-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-42125-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.