(3,4-Dihydroxybenzylidene)malononitrile

Also known as: Tyrphostin A23, Tyrphostin 23, AG 18, AG-18, RG-50810, 2-(3,4-Dihydroxybenzylidene)malononitrile, 2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile, [(3,4-Dihydroxyphenyl)methylene]propanedinitrile, Alpha-cyano-(3,4-dihydroxy)cinnamonitrile, MFCD00133899, Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-

(3,4-Dihydroxybenzylidene)malononitrile (CAS 118409-57-7) is a compound in the Nitrogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H6N2O2 and a molecular weight of 186.167 g/mol. Key properties include a melting point of 225ºC, a boiling point of 421.1±45.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 208.5±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 118409-57-7
Jingsj CID: J-39132-8
Molecular Formula: C₁₀H₆N₂O₂
Molecular Weight: 186.167 g/mol
Category: Nitrogen Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	225ºC
Boiling Point	421.1±45.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	208.5±28.7 °C
Exact Mass	186.042923
PSA	88.04000
LogP	0.99
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.697
Additional Property	Soluble in DMSO, ethanol, or DMF

Activity & Biological Data

Target	EGFR:35 μM (IC50, Cell Assay) EGFR:11 μM (Ki)
Additional Information	[1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40. [3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.

Target

EGFR:35 μM (IC50, Cell Assay) EGFR:11 μM (Ki)

Additional Information

[1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40. [3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.

Frequently Asked Questions

What is the CAS number of (3,4-Dihydroxybenzylidene)malononitrile?

The CAS number of (3,4-Dihydroxybenzylidene)malononitrile is 118409-57-7.

What are the molecular formula and molecular weight of (3,4-Dihydroxybenzylidene)malononitrile?

(3,4-Dihydroxybenzylidene)malononitrile has molecular formula C10H6N2O2 and molecular weight 186.167 g/mol.

What are the upstream and downstream products of (3,4-Dihydroxybenzylidene)malononitrile?

For (3,4-Dihydroxybenzylidene)malononitrile, Upstream Products: 3,4-Bis(methoxymethoxy)benzaldehyde, Malononitrile, 3,4-Dihydroxybenzaldehyde; Downstream Products: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(3,4-Dihydroxybenzylidene)malononitrile (CAS 118409-57-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-39132-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.