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Fmoc-His(Trt)-OH

Also known as: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine, Fmoc-His(1-Trt)-OH, Nα-Fmoc-N(im)-trityl-L-histidine, Nα-Fmoc-τ-trityl-L-histidine, MFCD00043332, N-alpha-FMOC-N-Trityl-L-histidine, Na-Fmoc-Nim-trityl-L-histidine, FMOC-HIS(TRT)-OH

Fmoc-His(Trt)-OH (CAS 109425-51-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C40H33N3O4 and a molecular weight of 619.708 g/mol. Key properties include a melting point of 150-155 °C(lit.), a boiling point of 811.7±65.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 444.7±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
109425-51-6
Jingsj CID
J-38362-0
Molecular Formula
C40H33N3O4
Molecular Weight
619.708 g/mol
Category
Organic Acids
Last updated
8/21/2026

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Physicochemical Properties

Melting Point150-155 °C(lit.)
Boiling Point811.7±65.0 °C at 760 mmHg
Density1.2±0.1 g/cm3
Flash Point444.7±34.3 °C
Exact Mass619.247131
PSA93.45000
LogP8.03
Vapor Pressure0.0±3.1 mmHg at 25°C
Refractive Index1.657

Activity & Biological Data

Additional Information[1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

Frequently Asked Questions

What is the CAS number of Fmoc-His(Trt)-OH?

The CAS number of Fmoc-His(Trt)-OH is 109425-51-6.

What are the molecular formula and molecular weight of Fmoc-His(Trt)-OH?

Fmoc-His(Trt)-OH has molecular formula C40H33N3O4 and molecular weight 619.708 g/mol.

What are the upstream and downstream products of Fmoc-His(Trt)-OH?

For Fmoc-His(Trt)-OH, Upstream Products: Fmoc-OSu, H-His(Trt)-OH, 9-Fluorenylmethyl chloroformate; Downstream Products: H-His(Trt)-OH, Copper Peptide, Angiotensin I/II (4-8).

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Fmoc-His(Trt)-OH (CAS 109425-51-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-38362-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.