Roscovitine (CYC202)

Also known as: (+)-Seliciclib, (2R)-2-{[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino}-1-butanol, (2R)-2-{[6-(Benzylamino)-9-isopropyl-9H-purin-2-yl]amino}butan-1-ol, (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol, (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol, (R)-Roscovitine, 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-, 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine, CYC 202, CYC202, CYC202 Cyclacel, MFCD02266401, P34 CDC2, R-roscovitine, Roscovitin, Seliciclib, seliciclib

Roscovitine (CYC202) (CAS 186692-46-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H26N6O and a molecular weight of 354.449 g/mol. Key properties include a boiling point of 577.5±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 303.1±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 186692-46-6
Jingsj CID: J-38030-3
Molecular Formula: C₁₉H₂₆N₆O
Molecular Weight: 354.449 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	577.5±60.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	303.1±32.9 °C
Exact Mass	354.216797
PSA	87.89000
LogP	1.68
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.643

Activity & Biological Data

Target	cdc2/cyclin B:0.65 μM (IC50) cdk2/cyclin A:0.7 μM (IC50) Cdk2/cyclin E2:0.7 μM (IC50) CDK5/p35:0.16 μM (IC50) GST-erk1:30 μM (IC50) erk1:34 μM (IC50) erk2:14 μM (IC50) Insulin-receptor tyrosine kinase:70 μM (IC50)
Additional Information	[1]. Meijer L, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36. [2]. Bai X, et al. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via erk1/2/pparγ pathway. Oncotarget. 2016 Apr 27. [3]. Gary C, et al. Selective antitumor activity of roscovitine in head and neck cancer. Oncotarget. 2016 May 23.

Target

cdc2/cyclin B:0.65 μM (IC50) cdk2/cyclin A:0.7 μM (IC50) Cdk2/cyclin E2:0.7 μM (IC50) CDK5/p35:0.16 μM (IC50) GST-erk1:30 μM (IC50) erk1:34 μM (IC50) erk2:14 μM (IC50) Insulin-receptor tyrosine kinase:70 μM (IC50)

Additional Information

[1]. Meijer L, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36. [2]. Bai X, et al. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via erk1/2/pparγ pathway. Oncotarget. 2016 Apr 27. [3]. Gary C, et al. Selective antitumor activity of roscovitine in head and neck cancer. Oncotarget. 2016 May 23.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Roscovitine (CYC202)?

The CAS number of Roscovitine (CYC202) is 186692-46-6.

What are the molecular formula and molecular weight of Roscovitine (CYC202)?

Roscovitine (CYC202) has molecular formula C19H26N6O and molecular weight 354.449 g/mol.

What are the upstream and downstream products of Roscovitine (CYC202)?

For Roscovitine (CYC202), Upstream Products: (R)-(-)-2-Amino-1-butanol, N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine, N-Benzyl-2-chloro-9H-purin-6-amine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Roscovitine (CYC202) (CAS 186692-46-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-38030-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.