![Molecular structure of N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide (CAS 391210-10-9)](/images/chem_structures_svg/014/391210-10-9.svg)
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Also known as: PD 0325901, PD0325901, (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide (CAS 391210-10-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C16H14F3IN2O4 and a molecular weight of 482.193 g/mol. Key properties include a melting point of 112-114ºC and a density of 1.8±0.1 g/cm3. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H373 — May cause damage to organs through prolonged exposure and H410 — Very toxic to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 391210-10-9
- Jingsj CID
- J-38029-0
- Molecular Formula
- C16H14F3IN2O4
- Molecular Weight
- 482.193 g/mol
- Category
- Organic Bases
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 112-114ºC |
|---|---|
| Density | 1.8±0.1 g/cm3 |
| Exact Mass | 481.995026 |
| PSA | 90.82000 |
| LogP | 6.16 |
| Appearance | white to off-white |
| Refractive Index | 1.645 |
| Storage Conditions | Store at -20°C |
| Additional Property | DMSO: soluble20mg/mL, clear |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H373 — May cause damage to organs through prolonged exposure
- H410 — Very toxic to aquatic life with long lasting effects
Activity & Biological Data
| Target | MEK1:0.33 nM (IC50) Autophagy |
|---|---|
| Additional Information | [1]. Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. [2]. Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010 Jul;9(7):1968-76. |
Frequently Asked Questions
What is the CAS number of N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?
The CAS number of N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide is 391210-10-9.
What are the molecular formula and molecular weight of N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide has molecular formula C16H14F3IN2O4 and molecular weight 482.193 g/mol.
Is N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide hazardous?
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H373 — May cause damage to organs through prolonged exposure; H410 — Very toxic to aquatic life with long lasting effects.
What are the upstream and downstream products of N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide?
For N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide, Upstream Products: 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, O-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]hydroxylamine hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide (CAS 391210-10-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-38029-0 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.