18α-Glycyrrhetinic acid

Also known as: 18alpha-Glycyrrhetinic acid, 18a-Glycyrrhetinic acid, 18a-Glycyrrhetic acid, Glycyrrhetic acid, Glycyrrhetinic acid (α-type), 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid, 3BETA-HYDROXY-11-OXO-18ALPHA,20BETA-OLEAN-12-EN-29-OIC ACID, Enoxolone impurity A, NSC 35350, 18-Isoglycyrrhetinic acid, β-Glycyrrhetinic acid (obsolete), Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,18α)-, MFCD00064897, EINECS 215-907-9

18α-Glycyrrhetinic acid (CAS 1449-05-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C30H46O4 and a molecular weight of 470.684 g/mol. Key properties include a melting point of 331-333°C, a boiling point of 588.3±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 323.7±26.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1449-05-4
Jingsj CID: J-37907-7
Molecular Formula: C₃₀H₄₆O₄
Molecular Weight: 470.684 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	331-333°C
Boiling Point	588.3±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	323.7±26.6 °C
Exact Mass	470.339600
PSA	74.60000
LogP	6.57
Vapor Pressure	0.0±3.7 mmHg at 25°C
Refractive Index	1.563

Activity & Biological Data

Target	NF-κB Proteasome
Additional Information	[1]. Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. J Dig Dis. 2013 Jun;14(6):328-36. [2]. Papaevgeniou N, et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal. 2016 Dec 1;25(16):855-869.

Target

NF-κB Proteasome

Additional Information

[1]. Zong L et al. 18α-glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line. J Dig Dis. 2013 Jun;14(6):328-36. [2]. Papaevgeniou N, et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. Antioxid Redox Signal. 2016 Dec 1;25(16):855-869.

Customs & Trade Information

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 18α-Glycyrrhetinic acid?

The CAS number of 18α-Glycyrrhetinic acid is 1449-05-4.

What are the molecular formula and molecular weight of 18α-Glycyrrhetinic acid?

18α-Glycyrrhetinic acid has molecular formula C30H46O4 and molecular weight 470.684 g/mol.

What are the upstream and downstream products of 18α-Glycyrrhetinic acid?

For 18α-Glycyrrhetinic acid, Upstream Products: Glycyrrhetinic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "18α-Glycyrrhetinic acid (CAS 1449-05-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37907-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.