(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide

Also known as: AG 99, (E)-AG 99, 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-, 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide, 3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE, 3,4-dihydroxybenzalcyanoacetamide, ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE, HMS3266G04, IN1036, TYRPHOSTIN 46, TYRPHOSTIN A46, TYRPHOSTIN AG 99, TYRPHOSTIN B40, Tyrphostin A46, Tyrphostin AG 99

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide (CAS 122520-85-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C10H8N2O3 and a molecular weight of 204.182 g/mol. Key properties include a melting point of 231 °C, a boiling point of 544.4±50.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 283.0±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 122520-85-8
Jingsj CID: J-37300-2
Molecular Formula: C₁₀H₈N₂O₃
Molecular Weight: 204.182 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	231 °C
Boiling Point	544.4±50.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	283.0±30.1 °C
Exact Mass	204.053497
PSA	107.34000
LogP	0.02
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.711
Storage Conditions	Desiccate at +4°C

Activity & Biological Data

Target	EGFR
Additional Information	[1]. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.

Frequently Asked Questions

What is the CAS number of (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide?

The CAS number of (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide is 122520-85-8.

What are the molecular formula and molecular weight of (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide?

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide has molecular formula C10H8N2O3 and molecular weight 204.182 g/mol.

What are the upstream and downstream products of (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide?

For (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide, Upstream Products: 3,4-Dihydroxybenzaldehyde, 2-Cyanoacetamide, (3,4-Dihydroxybenzylidene)malononitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "(E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide (CAS 122520-85-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37300-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.