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(R)-(+)-4-Hydroxy-2-pyrrolidinone

Also known as: (R)-4-Hydroxy-2-pyrrolidinone, (R)-4-Hydroxy-2-pyrrolidone, (4R)-4-Hydroxypyrrolidin-2-one, (4R)-4-hydroxy-2-pyrrolidinone, (R)-4-Hydroxypyrrolidin-2-one, (R)-beta-Hydroxy-gamma-butyrolactam, 2-Pyrrolidinone, 4-hydroxy-, (4R)-

(R)-(+)-4-Hydroxy-2-pyrrolidinone (CAS 22677-21-0) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C4H7NO2 and a molecular weight of 101.104 g/mol. Key properties include a melting point of 156-160ºC, a boiling point of 363.6±35.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 173.7±25.9 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
22677-21-0
Jingsj CID
J-37254-3
Molecular Formula
C4H7NO2
Molecular Weight
101.104 g/mol
Category
Ketones
Last updated
8/21/2026

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Physicochemical Properties

Melting Point156-160ºC
Boiling Point363.6±35.0 °C at 760 mmHg
Density1.3±0.1 g/cm3
Flash Point173.7±25.9 °C
Exact Mass101.047676
PSA49.33000
LogP-2.55
Vapor Pressure0.0±1.8 mmHg at 25°C
Refractive Index1.513

GHS Safety & Compliance

IrritantSignal word: Warning
  • H315 — Causes skin irritation
  • H319 — Causes serious eye irritation
  • H335 — May cause respiratory irritation

Customs & Trade Information

HS Code2933790090
Summary2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of (R)-(+)-4-Hydroxy-2-pyrrolidinone?

The CAS number of (R)-(+)-4-Hydroxy-2-pyrrolidinone is 22677-21-0.

What are the molecular formula and molecular weight of (R)-(+)-4-Hydroxy-2-pyrrolidinone?

(R)-(+)-4-Hydroxy-2-pyrrolidinone has molecular formula C4H7NO2 and molecular weight 101.104 g/mol.

Is (R)-(+)-4-Hydroxy-2-pyrrolidinone hazardous?

(R)-(+)-4-Hydroxy-2-pyrrolidinone has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of (R)-(+)-4-Hydroxy-2-pyrrolidinone?

For (R)-(+)-4-Hydroxy-2-pyrrolidinone, Upstream Products: Ethyl 4-chloro-3-hydroxybutanoate; Downstream Products: (R)-4-Amino-3-hydroxybutanoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "(R)-(+)-4-Hydroxy-2-pyrrolidinone (CAS 22677-21-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37254-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.