4-Phenylbutyric acid

Also known as: 4-Phenylbutanoic acid, Benzenebutanoic acid, Benzenebutyric acid, gamma-Phenylbutyric acid, gamma-Phenyl-n-butyric acid, 4-Phenyl-n-butyric acid, 4-PHENYLBUTYRIC ACID, PHENYLBUTYRIC ACID, NSC 295, Buphenyl

4-Phenylbutyric acid (CAS 1821-12-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C10H12O2 and a molecular weight of 164.201 g/mol. Key properties include a melting point of 49-52ºC, a boiling point of 290.7±9.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 187.9±13.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1821-12-1
Jingsj CID: J-37175-5
Molecular Formula: C₁₀H₁₂O₂
Molecular Weight: 164.201 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	49-52ºC
Boiling Point	290.7±9.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	187.9±13.9 °C
Exact Mass	164.083725
PSA	37.30000
LogP	2.42
Vapor Pressure	0.0±0.6 mmHg at 25°C
Refractive Index	1.535
Additional Property	5.3 g/L at 40 ºC

Activity & Biological Data

Target	HDAC
Additional Information	[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [3]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Target

HDAC

Additional Information

[1]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [2]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. [3]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Customs & Trade Information

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 4-Phenylbutyric acid?

The CAS number of 4-Phenylbutyric acid is 1821-12-1.

What are the molecular formula and molecular weight of 4-Phenylbutyric acid?

4-Phenylbutyric acid has molecular formula C10H12O2 and molecular weight 164.201 g/mol.

What are the upstream and downstream products of 4-Phenylbutyric acid?

For 4-Phenylbutyric acid, Upstream Products: 4-Phenyl-1-butanol, 4-Phenylbut-3-enoic acid, Diethyl 2-(phenylethyl)malonate; Downstream Products: 4-(2-Nitrophenyl)butanoic acid, 4-(4-Nitrophenyl)butyric acid, 3-(1-Naphthyl)propionic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Phenylbutyric acid (CAS 1821-12-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-37175-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.