Pemetrexed
Also known as: Pemetrexed acid, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, LY231514, Alimta (free acid), N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid, MFCD00902635
Pemetrexed (CAS 137281-23-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H21N5O6 and a molecular weight of 427.411 g/mol. Key property: a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 137281-23-3
- Jingsj CID
- J-36699-4
- Molecular Formula
- C20H21N5O6
- Molecular Weight
- 427.411 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Exact Mass | 427.149170 |
| PSA | 191.26000 |
| LogP | -0.03 |
| Refractive Index | 1.724 |
Activity & Biological Data
| Target | Ki: 1.3 nM (TS), 7.2 nM (DHFR), 65 nM (GARFT)[1] |
|---|---|
| Additional Information | [1]. Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]. Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Pemetrexed?
The CAS number of Pemetrexed is 137281-23-3.
What are the molecular formula and molecular weight of Pemetrexed?
Pemetrexed has molecular formula C20H21N5O6 and molecular weight 427.411 g/mol.
What are the upstream and downstream products of Pemetrexed?
For Pemetrexed, Upstream Products: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 4-methylbenzenesulfonate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Pemetrexed (CAS 137281-23-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-36699-4 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.