Rhein

Also known as: 1,8-dihydroxy-3-carboxyanthraquinone, 4,5-dihydroxyanthraquinone-2-carboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, cassic acid, chrysazin-3-carboxylic acid, monorhein, rheic acid, rhubarb yellow

Rhein (CAS 478-43-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C15H8O6 and a molecular weight of 284.220 g/mol. Key properties include a melting point of ≥300 °C(lit.), a boiling point of 597.8±50.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 329.4±26.6 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Nov 3, 2026.

CAS No.: 478-43-3
Jingsj CID: J-3565-4
Molecular Formula: C₁₅H₈O₆
Molecular Weight: 284.220 g/mol
Category: Organic Acids
Last updated: 11/3/2026

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Physicochemical Properties

Melting Point	≥300 °C(lit.)
Boiling Point	597.8±50.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3
Flash Point	329.4±26.6 °C
Exact Mass	284.032074
PSA	111.90000
LogP	4.58
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.761
Additional Property	<0.1 g/100 mL at 17 ºC

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27–33. [2]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34. [3]. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.

Additional Information

[1]. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27–33. [2]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34. [3]. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.

Customs & Trade Information

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Rhein?

The CAS number of Rhein is 478-43-3.

What are the molecular formula and molecular weight of Rhein?

Rhein has molecular formula C15H8O6 and molecular weight 284.220 g/mol.

Is Rhein hazardous?

Rhein has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Rhein?

For Rhein, Upstream Products: Diacerein, Chrysophanol, Aloe-emodin; Downstream Products: 1,8-Dihydroxyanthraquinone, Diacerein.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 11/3/2026

How to cite: Jingsj. "Rhein (CAS 478-43-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-3565-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.