Monocrotaline

Also known as: Crotaline, Monocrotaline, Crotalin, Monocrotalin, (13α,14α)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione

Monocrotaline (CAS 315-22-0) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C16H23NO6 and a molecular weight of 325.357 g/mol. Key properties include a melting point of 204ºC (dec.)(lit.), a boiling point of 537.3±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 278.7±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H351 — Suspected of causing cancer. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 315-22-0
Jingsj CID: J-35547-5
Molecular Formula: C₁₆H₂₃NO₆
Molecular Weight: 325.357 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	204ºC (dec.)(lit.)
Boiling Point	537.3±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	278.7±30.1 °C
Exact Mass	325.152527
PSA	96.30000
LogP	-0.37
Vapor Pressure	0.0±3.2 mmHg at 25°C
Refractive Index	1.586

GHS Safety & Compliance

Acute Toxicity / Health HazardSignal word: Danger

H301 — Toxic if swallowed
H351 — Suspected of causing cancer

Activity & Biological Data

Additional Information	[1]. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9. [2]. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48. [3]. Wilson DW, et, al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992;22(5-6):307-25. [4]. Nogueira-Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec;35:8-16. [5]. Rafikova O,et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3;11(3):e0150480.

Additional Information

[1]. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9. [2]. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48. [3]. Wilson DW, et, al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992;22(5-6):307-25. [4]. Nogueira-Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec;35:8-16. [5]. Rafikova O,et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3;11(3):e0150480.

Frequently Asked Questions

What is the CAS number of Monocrotaline?

The CAS number of Monocrotaline is 315-22-0.

What are the molecular formula and molecular weight of Monocrotaline?

Monocrotaline has molecular formula C16H23NO6 and molecular weight 325.357 g/mol.

Is Monocrotaline hazardous?

Monocrotaline has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H351 — Suspected of causing cancer.

What are the upstream and downstream products of Monocrotaline?

For Monocrotaline, Downstream Products: meso-2,3-Dimethylsuccinic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Monocrotaline (CAS 315-22-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-35547-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.