Niflumic acid
Also known as: 2-(3-Trifluoromethylanilino)nicotinic acid, 2-[3-(Trifluoromethyl)anilino]nicotinic acid, 2-[(3-Trifluoromethylphenyl)amino]nicotinic acid, 2-(α,α,α-trifluoro-m-toluidino)nicotinic acid, 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid, 2-{[3-(Trifluoromethyl)phenyl]amino}nicotinic acid, 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, ACIDUM NIFLUMICUM, Niflumate
Niflumic acid (CAS 4394-00-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C13H9F3N2O2 and a molecular weight of 282.218 g/mol. Key properties include a melting point of 203-204ºC, a boiling point of 378.0±42.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 182.4±27.9 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H332 — Harmful if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 4394-00-7
- Jingsj CID
- J-33694-5
- Molecular Formula
- C13H9F3N2O2
- Molecular Weight
- 282.218 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 203-204ºC |
|---|---|
| Boiling Point | 378.0±42.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 182.4±27.9 °C |
| Exact Mass | 282.061615 |
| PSA | 62.22000 |
| LogP | 4.94 |
| Vapor Pressure | 0.0±0.9 mmHg at 25°C |
| Refractive Index | 1.589 |
| Additional Property | Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (~50 mg/ml). |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H312 — Harmful in contact with skin
- H332 — Harmful if inhaled
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Additional Information | [1]. Criddle, D.N., et al., Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol, 1997. 120(5): p. 813-8. [2]. Jabeen, T., et al., Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr, 2005. 61(Pt 12): p. 1579- [3]. Picollo, A., et al., Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol, 2007. 216(2-3): p. 73-82. |
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Customs & Trade Information
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Niflumic acid?
The CAS number of Niflumic acid is 4394-00-7.
What are the molecular formula and molecular weight of Niflumic acid?
Niflumic acid has molecular formula C13H9F3N2O2 and molecular weight 282.218 g/mol.
Is Niflumic acid hazardous?
Niflumic acid has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H332 — Harmful if inhaled.
What are the upstream and downstream products of Niflumic acid?
For Niflumic acid, Upstream Products: 2-Chloronicotinic acid, 3-(Trifluoromethyl)aniline; Downstream Products: Talniflumate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Niflumic acid (CAS 4394-00-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33694-5 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.