Simvastatin

Also known as: Zocor, Lipex, Lipovas, Zocord, Simvotin, Sivastin, Velostatin, Denan, Eucor, Rechol, Simcor, Valemia, Cholestat, Coledis, Colemin, Corolin, Kolestevan, Lipinorm, Liponorm, Modutrol

Simvastatin (CAS 79902-63-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H38O5 and a molecular weight of 418.566 g/mol. Key properties include a melting point of 139 °C, a boiling point of 564.9±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 184.8±23.6 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 79902-63-9
Jingsj CID: J-33650-5
Molecular Formula: C₂₅H₃₈O₅
Molecular Weight: 418.566 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	139 °C
Boiling Point	564.9±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	184.8±23.6 °C
Exact Mass	418.271912
PSA	72.83000
LogP	4.41
Vapor Pressure	0.0±3.5 mmHg at 25°C
Refractive Index	1.530

Activity & Biological Data

Target	Ki: 0.2 nM (HMG-CoA reductase)[1]
Additional Information	[1]. Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82. [2]. Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med, 2000. 6(9): p. 1004-10. [3]. Leung BP, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol. 2003 Feb 1;170(3):1524-30. [4]. Kobayashi M, et al. Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Jpn J Pharmacol. 1989 Jan;49(1):125-33. [5]. Ishida F, et al. Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits. Biochim Biophys Acta. 1990 Feb 23;1042(3):365-73. [6]. Sukhova GK, et al. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1452-8. [7]. Weijiang Dong, et al. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct; 50(10): 2095-2102. [8]. Liu Z, et al. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxid Med Cell Longev. 2017;2017:3861914.

Target

Ki: 0.2 nM (HMG-CoA reductase)[1]

Additional Information

[1]. Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82. [2]. Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med, 2000. 6(9): p. 1004-10. [3]. Leung BP, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol. 2003 Feb 1;170(3):1524-30. [4]. Kobayashi M, et al. Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Jpn J Pharmacol. 1989 Jan;49(1):125-33. [5]. Ishida F, et al. Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits. Biochim Biophys Acta. 1990 Feb 23;1042(3):365-73. [6]. Sukhova GK, et al. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1452-8. [7]. Weijiang Dong, et al. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct; 50(10): 2095-2102. [8]. Liu Z, et al. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxid Med Cell Longev. 2017;2017:3861914.

Frequently Asked Questions

What is the CAS number of Simvastatin?

The CAS number of Simvastatin is 79902-63-9.

What are the molecular formula and molecular weight of Simvastatin?

Simvastatin has molecular formula C25H38O5 and molecular weight 418.566 g/mol.

What are the upstream and downstream products of Simvastatin?

For Simvastatin, Upstream Products: Simvastatin ammonium salt, Acetyl simvastatin, Pyridine hydrobromide; Downstream Products: Anhydrosimvastatin, tert-Butanol, Simvastatin hydroxy acid sodium salt.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Simvastatin (CAS 79902-63-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33650-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.