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Hexamethylphosphoramide

Also known as: Hexamethylphosphoric triamide, Tris(dimethylamino)phosphine oxide, HMPA, HMPTA, Hexametapol, Eastman Inhibitor HPT, ENT 50,882, ENT 50882, Phosphoric acid hexamethyltriamide, N,N,N',N',N'',N''-hexamethylphosphoric triamide, HPT, MFCD00008303, EINECS 211-653-8, HEMPA

Hexamethylphosphoramide (CAS 680-31-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C6H18N3OP and a molecular weight of 179.20000 g/mol. Key properties include a melting point of 7 °C(lit.), a boiling point of 230-232 °C740 mm Hg(lit.), a density of 1.03 g/mL at 25 °C(lit.) and a flash point of 105.6 °C. It is classified under GHS with signal word Danger and hazard statements H340 and H350 — May cause cancer. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.

CAS No.
680-31-9
Jingsj CID
J-33403-3
Molecular Formula
C6H18N3OP
Molecular Weight
179.20000 g/mol
Category
Organic Bases
Last updated
11/2/2026

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Physicochemical Properties

Melting Point7 °C(lit.)
Boiling Point230-232 °C740 mm Hg(lit.)
Density1.03 g/mL at 25 °C(lit.)
Flash Point105.6 °C
Exact Mass179.11900
PSA36.60000
LogP0.77930
Additional Property6.18 (vs air)
Vapor Pressure0.07 mm Hg ( 25 °C)
Refractive Indexn20/D 1.459(lit.)
Additional PropertyMiscible
Additional Property7℃

GHS Safety & Compliance

Health HazardSignal word: Danger
  • H340
  • H350 — May cause cancer

Frequently Asked Questions

What is the CAS number of Hexamethylphosphoramide?

The CAS number of Hexamethylphosphoramide is 680-31-9.

What are the molecular formula and molecular weight of Hexamethylphosphoramide?

Hexamethylphosphoramide has molecular formula C6H18N3OP and molecular weight 179.20000 g/mol.

Is Hexamethylphosphoramide hazardous?

Hexamethylphosphoramide has GHS signal word Danger and hazard statements H340; H350 — May cause cancer.

What are the upstream and downstream products of Hexamethylphosphoramide?

For Hexamethylphosphoramide, Upstream Products: Tris(dimethylamino)phosphine, Bis(dimethylamino)phosphoryl chloride, Triphenylphosphine; Downstream Products: Methyl 4,4-dimethyl-3-oxopentanoate, Imino-tris(dimethylamino)phosphorane, 2-Methylpyridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "Hexamethylphosphoramide (CAS 680-31-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33403-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.