Clofarabine
Also known as: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine, 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine, CAFDA, Cl-F-Ara-A, Clofarex, Clolar, Evoltra, (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, MFCD00871077
Clofarabine (CAS 123318-82-1) is a compound in the Organohalogen Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H11ClFN5O3 and a molecular weight of 303.677 g/mol. Key properties include a melting point of 228-231 °C, a boiling point of 599.5±60.0 °C at 760 mmHg, a density of 2.1±0.1 g/cm3 and a flash point of 316.4±32.9 °C. It is classified under GHS with signal word Danger and hazard statements H300. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 123318-82-1
- Jingsj CID
- J-33145-3
- Molecular Formula
- C10H11ClFN5O3
- Molecular Weight
- 303.677 g/mol
- Category
- Organohalogen Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 228-231 °C |
|---|---|
| Boiling Point | 599.5±60.0 °C at 760 mmHg |
| Density | 2.1±0.1 g/cm3 |
| Flash Point | 316.4±32.9 °C |
| Exact Mass | 303.053436 |
| PSA | 119.31000 |
| LogP | 0.24 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.844 |
GHS Safety & Compliance
- H300
Activity & Biological Data
| Additional Information | [1]. Bonate et al Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov. (2006)5 855. [2]. Ghanem H, Kantarjian H, Ohanian M, Jabbour E.The Role of Clofarabine in Acute Myeloid Leukemia.Leuk Lymphoma. 2012 Sep 7. [3]. Abd Elmoneim A, Gore L, Ricklis RM, Boklan J, Cooper T, Narendran A, Rolla K, Scott T, Arceci RJ.Phase I dose-escalation trial of clofarabine followed by escalating doses of fractionated cyclophosphamide in children with relapsed or refractory acute leukemias.Pediatr Blood Cancer. 2012 Aug 8. doi: 10.1002/pbc.24264. [4]. Thudium KE, Ghoshal S, Fetterly GJ, Haese JP, Karpf AR, Wetzler M.Synergism between clofarabine and decitabine through p53R2: A pharmacodynamic drug-drug interaction modeling.Leuk Res. 2012 Aug 9. [5]. Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J.Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers.Chem Biol. 2012 Jul 27;19(7):799-805. |
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Frequently Asked Questions
What is the CAS number of Clofarabine?
The CAS number of Clofarabine is 123318-82-1.
What are the molecular formula and molecular weight of Clofarabine?
Clofarabine has molecular formula C10H11ClFN5O3 and molecular weight 303.677 g/mol.
Is Clofarabine hazardous?
Clofarabine has GHS signal word Danger and hazard statements H300.
What are the upstream and downstream products of Clofarabine?
For Clofarabine, Upstream Products: 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose, 2-Deoxy-2-fluoro-alpha-D-arabinofuranosyl bromide 3,5-dibenzoate, beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate; Downstream Products: 2-Chloroadenine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Clofarabine (CAS 123318-82-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-33145-3 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.