Closantel

Also known as: Closantel, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-, UNII-EUL532EI54, MFCD00661151, rac-N-[5-chloro-4-[(R)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, Faskoverm

Closantel (CAS 57808-65-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C22H14Cl2I2N2O2 and a molecular weight of 663.074 g/mol. Key properties include a melting point of 210 - 22ºC, a boiling point of 590.5±50.0 °C at 760 mmHg, a density of 1.9±0.1 g/cm3 and a flash point of 310.9±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed and H413. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 57808-65-8
Jingsj CID: J-32739-9
Molecular Formula: C₂₂H₁₄Cl₂I₂N₂O₂
Molecular Weight: 663.074 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	210 - 22ºC
Boiling Point	590.5±50.0 °C at 760 mmHg
Density	1.9±0.1 g/cm3
Flash Point	310.9±30.1 °C
Exact Mass	661.852173
PSA	73.12000
LogP	9.08
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.736
Storage Conditions	0-6°C

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H413

Activity & Biological Data

Additional Information	[1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8. [2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45. [3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71.

Additional Information

[1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8. [2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45. [3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71.

Frequently Asked Questions

What is the CAS number of Closantel?

The CAS number of Closantel is 57808-65-8.

What are the molecular formula and molecular weight of Closantel?

Closantel has molecular formula C22H14Cl2I2N2O2 and molecular weight 663.074 g/mol.

Is Closantel hazardous?

Closantel has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H413.

What are the upstream and downstream products of Closantel?

For Closantel, Upstream Products: 1,4-Dioxane, 3,5-Diiodosalicyloyl chloride, 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Closantel (CAS 57808-65-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-32739-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.