4-Hydroxyestrone

Also known as: 4-Hydroxy Estrone, Estrone 4-Hydroxy Impurity, MFCD00079358, 1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE, 3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE, 3,4-dihydroxyestra-1,3,5(10)-trien-17-one, (8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

4-Hydroxyestrone (CAS 3131-23-5) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C18H22O3 and a molecular weight of 286.36500 g/mol. Key properties include a melting point of 260-263ºC, a boiling point of 468.2ºC at 760mmHg, a density of 1.241g/cm3 and a flash point of 251.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 3131-23-5
Jingsj CID: J-31205-0
Molecular Formula: C₁₈H₂₂O₃
Molecular Weight: 286.36500 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	260-263ºC
Boiling Point	468.2ºC at 760mmHg
Density	1.241g/cm3
Flash Point	251.1ºC
Exact Mass	286.15700
PSA	57.53000
LogP	3.52300
Refractive Index	1.61

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283.

Frequently Asked Questions

What is the CAS number of 4-Hydroxyestrone?

The CAS number of 4-Hydroxyestrone is 3131-23-5.

What are the molecular formula and molecular weight of 4-Hydroxyestrone?

4-Hydroxyestrone has molecular formula C18H22O3 and molecular weight 286.36500 g/mol.

What are the upstream and downstream products of 4-Hydroxyestrone?

For 4-Hydroxyestrone, Upstream Products: Estrone, 19-Nor-4-androstene-3,17-dione; Downstream Products: 4-Hydroxyestradiol, 4-Methoxyestrone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Hydroxyestrone (CAS 3131-23-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31205-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.