Tamibarotene

Also known as: Tamibarotene, Am 80, Am 80 (pharmaceutical), Amnolake, NSC 608000, Retinoid AM 80, 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid, Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-, SY 1425, TM 441, OP 01, RR 110, INNO 507, TOS 80T

Tamibarotene (CAS 94497-51-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H25NO3 and a molecular weight of 351.439 g/mol. Key properties include a melting point of 231-232ºC, a boiling point of 449.6±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 225.7±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 94497-51-5
Jingsj CID: J-31077-0
Molecular Formula: C₂₂H₂₅NO₃
Molecular Weight: 351.439 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	231-232ºC
Boiling Point	449.6±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	225.7±28.7 °C
Exact Mass	351.183441
PSA	66.40000
LogP	6.48
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.593

Activity & Biological Data

Target	RARα/β[1]
Additional Information	[1]. Wang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255. [2]. Toyama T, et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb;136(2):387-98. [3]. Jin Y, et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23(2):537-45. [4]. Lv XR, et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456(1):35-46. [5]. Kitaoka K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65.

Target

RARα/β[1]

Additional Information

[1]. Wang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255. [2]. Toyama T, et al. Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells. J Invest Dermatol. 2016 Feb;136(2):387-98. [3]. Jin Y, et al. Tamibarotene modulates the local immune response in experimental periodontitis. Int Immunopharmacol. 2014 Dec;23(2):537-45. [4]. Lv XR, et al. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells. Biochem J. 2013 Nov 15;456(1):35-46. [5]. Kitaoka K, et al. The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice. Neuropharmacology. 2013 Sep;72:58-65.

Customs & Trade Information

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Tamibarotene?

The CAS number of Tamibarotene is 94497-51-5.

What are the molecular formula and molecular weight of Tamibarotene?

Tamibarotene has molecular formula C22H25NO3 and molecular weight 351.439 g/mol.

What are the upstream and downstream products of Tamibarotene?

For Tamibarotene, Upstream Products: Methyl 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoate, 2,5-Dimethyl-2,5-hexanediol, 2,5-Dichloro-2,5-dimethylhexane; Downstream Products: Methyl 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tamibarotene (CAS 94497-51-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31077-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.