(-)-Cotinine
Also known as: Cotinine, (S)-(-)-Cotinine, (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone, (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone, 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-
(-)-Cotinine (CAS 486-56-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C10H12N2O and a molecular weight of 176.215 g/mol. Key properties include a melting point of 40-42ºC, a boiling point of 316.0±0.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 166.7±25.9 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H301 — Toxic if swallowed and H311 — Toxic in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 486-56-6
- Jingsj CID
- J-31036-3
- Molecular Formula
- C10H12N2O
- Molecular Weight
- 176.215 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 40-42ºC |
|---|---|
| Boiling Point | 316.0±0.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 166.7±25.9 °C |
| Exact Mass | 176.094955 |
| PSA | 33.20000 |
| LogP | -0.23 |
| Vapor Pressure | 0.0±0.6 mmHg at 25°C |
| Refractive Index | 1.556 |
| Additional Property | Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform. |
GHS Safety & Compliance
- H225 — Highly flammable liquid and vapour
- H301 — Toxic if swallowed
- H311 — Toxic in contact with skin
- H331 — Toxic if inhaled
- H370 — Causes damage to organs
Activity & Biological Data
| Target | Human Endogenous Metabolite |
|---|
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of (-)-Cotinine?
The CAS number of (-)-Cotinine is 486-56-6.
What are the molecular formula and molecular weight of (-)-Cotinine?
(-)-Cotinine has molecular formula C10H12N2O and molecular weight 176.215 g/mol.
Is (-)-Cotinine hazardous?
(-)-Cotinine has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H301 — Toxic if swallowed; H311 — Toxic in contact with skin.
What are the upstream and downstream products of (-)-Cotinine?
For (-)-Cotinine, Downstream Products: β-Nicotyrine, S-(-)-Nicotine-Δ1'(5')-iminium Diperchlorate Salt.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "(-)-Cotinine (CAS 486-56-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-31036-3 (accessed 2026-11-07).
Data for reference only; verify product details with suppliers before purchase.