4-Hydroxyphenylacetic acid
Also known as: p-Hydroxyphenylacetic acid, 4-Hydroxybenzeneacetic acid, 2-(4-Hydroxyphenyl)acetic acid, (4-Hydroxyphenyl)acetic acid, (p-hydroxyphenyl)acetic acid, 4-carboxymethylphenol, NSC 27460, PHPA
4-Hydroxyphenylacetic acid (CAS 156-38-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H8O3 and a molecular weight of 152.147 g/mol. Key properties include a melting point of 148-151 °C(lit.), a boiling point of 346.6±17.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 177.6±17.4 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 156-38-7
- Jingsj CID
- J-29539-6
- Molecular Formula
- C8H8O3
- Molecular Weight
- 152.147 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 148-151 °C(lit.) |
|---|---|
| Boiling Point | 346.6±17.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 177.6±17.4 °C |
| Exact Mass | 152.047348 |
| PSA | 57.53000 |
| LogP | 0.77 |
| Vapor Pressure | 0.0±0.8 mmHg at 25°C |
| Refractive Index | 1.596 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | Nrf2[1] |
|---|---|
| Additional Information | [1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. |
Customs & Trade Information
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of 4-Hydroxyphenylacetic acid?
The CAS number of 4-Hydroxyphenylacetic acid is 156-38-7.
What are the molecular formula and molecular weight of 4-Hydroxyphenylacetic acid?
4-Hydroxyphenylacetic acid has molecular formula C8H8O3 and molecular weight 152.147 g/mol.
Is 4-Hydroxyphenylacetic acid hazardous?
4-Hydroxyphenylacetic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of 4-Hydroxyphenylacetic acid?
For 4-Hydroxyphenylacetic acid, Upstream Products: 4-Hydroxyphenethyl alcohol, 4-Methoxyphenylacetic acid, 4-Hydroxyphenylacetonitrile; Downstream Products: Isoxepac, Coelenterazine, 3-Chloro-4-hydroxyphenylacetic acid.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "4-Hydroxyphenylacetic acid (CAS 156-38-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-29539-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.