Chlorotrianisene

Also known as: Chlorotrianisene, TACE, Merbentul, Chlorestrolo, Chlortrianisestrol, Chlortrianizen, Chlorotrianisine, Chlorotrianizen, 1,1',1''-(1-Chloro-1,2,2-ethenetriyl)tris[4-methoxybenzene], 1-Chloro-1,2,2-tris(4-methoxyphenyl)ethene, 1-[2-chloro-1,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene, chlorotris(4-methoxyphenyl)ethylene, Tris(p-methoxyphenyl)chloroethylene

Chlorotrianisene (CAS 569-57-3) is a compound in the Ethers category listed in the Jingsj chemical database. It has the molecular formula C23H21ClO3 and a molecular weight of 380.86400 g/mol. Key properties include a melting point of 114-116ºC, a boiling point of 514.2ºC at 760mmHg, a density of 1.168g/cm3 and a flash point of 164.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 569-57-3
Jingsj CID: J-28639-8
Molecular Formula: C₂₃H₂₁ClO₃
Molecular Weight: 380.86400 g/mol
Category: Ethers
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	114-116ºC
Boiling Point	514.2ºC at 760mmHg
Density	1.168g/cm3
Flash Point	164.1ºC
Exact Mass	380.11800
PSA	27.69000
LogP	5.86780
Refractive Index	1.591
Storage Conditions	-70°C

Activity & Biological Data

Target	Estrogen receptor[1] COX-1[2]
Additional Information	[1]. Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):203-9. [2]. Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486(7403):361-7. [3]. Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62.

Target

Estrogen receptor[1] COX-1[2]

Additional Information

[1]. Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):203-9. [2]. Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486(7403):361-7. [3]. Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62.

Frequently Asked Questions

What is the CAS number of Chlorotrianisene?

The CAS number of Chlorotrianisene is 569-57-3.

What are the molecular formula and molecular weight of Chlorotrianisene?

Chlorotrianisene has molecular formula C23H21ClO3 and molecular weight 380.86400 g/mol.

What are the upstream and downstream products of Chlorotrianisene?

For Chlorotrianisene, Upstream Products: Anisole, 2-(4-methoxyphenyl)-2-oxoacetaldehyde, Methoxychlor; Downstream Products: 4,4'-Dimethoxybenzophenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Chlorotrianisene (CAS 569-57-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28639-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.