Sapropterin dihydrochloride

Also known as: (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride, (6R)-Tetrahydrobiopterin dihydrochloride, 6R-BH4 dihydrochloride, Sapropterin hydrochloride, Sapropterin, Biopten, Kuvan, (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride, 6R-Tetrahydro-L-biopterin, R-THBP dihydrochloride

Sapropterin dihydrochloride (CAS 69056-38-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C9H17Cl2N5O3 and a molecular weight of 314.17 g/mol. Key properties include a boiling point of 506.6±60.0 °C at 760 mmHg, a density of 1.9±0.1 g/cm3 and a flash point of 260.2±32.9 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 69056-38-8
Jingsj CID: J-28622-6
Molecular Formula: C₉H₁₇Cl₂N₅O₃
Molecular Weight: 314.17 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	506.6±60.0 °C at 760 mmHg
Density	1.9±0.1 g/cm3
Flash Point	260.2±32.9 °C
PSA	136.29000
LogP	-4.22
Vapor Pressure	0.0±3.0 mmHg at 25°C
Refractive Index	1.822

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Additional Information	[1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11. [2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27 [3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331. [4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16

Additional Information

[1]. Winn SR et al. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Mol Genet Metab. 2016 Jan;117(1):5-11. [2]. Somaraju UR et al. Sapropterin dihydrochloride for phenylketonuria. Cochrane Database Syst Rev. 2015 Mar 27 [3]. Jurecki ER et al. Sapropterin Dihydrochloride Mixed With Common Foods and Beverages. Top Clin Nutr. 2014 Oct;29(4):325-331. [4]. Grange DK et al. Sapropterin dihydrochloride use in pregnant women with phenylketonuria: an interim report of the PKU MOMS sub-registry. Mol Genet Metab. 2014 May;112(1):9-16

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Sapropterin dihydrochloride?

The CAS number of Sapropterin dihydrochloride is 69056-38-8.

What are the molecular formula and molecular weight of Sapropterin dihydrochloride?

Sapropterin dihydrochloride has molecular formula C9H17Cl2N5O3 and molecular weight 314.17 g/mol.

Is Sapropterin dihydrochloride hazardous?

Sapropterin dihydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Sapropterin dihydrochloride?

For Sapropterin dihydrochloride, Upstream Products: 6-Biopterin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Sapropterin dihydrochloride (CAS 69056-38-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28622-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.