Avagacestat

Also known as: BMS-708163, BMS 708163, BMS708163, CS-262, (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, (R)-2-(4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide

Avagacestat (CAS 1146699-66-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H17ClF4N4O4S and a molecular weight of 520.885 g/mol. Key properties include a boiling point of 652.3±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 348.3±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1146699-66-2
Jingsj CID: J-28216-6
Molecular Formula: C₂₀H₁₇ClF₄N₄O₄S
Molecular Weight: 520.885 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	652.3±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	348.3±34.3 °C
Exact Mass	520.059509
PSA	127.77000
LogP	4.89
Vapor Pressure	0.0±2.0 mmHg at 25°C
Refractive Index	1.564
Storage Conditions	-20℃

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	IC50: 0.27 nM (γ-secretase, Aβ42), 0.30 nM (γ-secretase, Aβ40), 20 μM (CYP2C19)[1], 0.84 nM (NICD)[2]
Additional Information	[1]. Gillman KW, et al. Letter Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Med Chem Lett, 2010, 1 (3), 120-124. [2]. Crump CJ, et al. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18;51(37):7209-11. [3]. Xie M, et al. γ Secretase inhibitor BMS-708163 reverses resistance to EGFR inhibitor via the PI3K/Akt pathway in lung cancer. J Cell Biochem. 2015 Jun;116(6):1019-27. [4]. Borghys H, et al. A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators. J Alzheimers Dis. 2012;28(4):809-22.

Target

IC50: 0.27 nM (γ-secretase, Aβ42), 0.30 nM (γ-secretase, Aβ40), 20 μM (CYP2C19)[1], 0.84 nM (NICD)[2]

Additional Information

[1]. Gillman KW, et al. Letter Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Med Chem Lett, 2010, 1 (3), 120-124. [2]. Crump CJ, et al. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 2012 Sep 18;51(37):7209-11. [3]. Xie M, et al. γ Secretase inhibitor BMS-708163 reverses resistance to EGFR inhibitor via the PI3K/Akt pathway in lung cancer. J Cell Biochem. 2015 Jun;116(6):1019-27. [4]. Borghys H, et al. A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators. J Alzheimers Dis. 2012;28(4):809-22.

Frequently Asked Questions

What is the CAS number of Avagacestat?

The CAS number of Avagacestat is 1146699-66-2.

What are the molecular formula and molecular weight of Avagacestat?

Avagacestat has molecular formula C20H17ClF4N4O4S and molecular weight 520.885 g/mol.

Is Avagacestat hazardous?

Avagacestat has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Avagacestat (CAS 1146699-66-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28216-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.