Tetrabenazine

Also known as: Nitoman, Rubigen, Xenazine, Ro 1-9569, 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, 9,10-Dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one, cis-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one, Tetrabenazine Racemate, 1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one

Tetrabenazine (CAS 58-46-8) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C19H27NO3 and a molecular weight of 317.423 g/mol. Key properties include a melting point of 128-130ºC, a boiling point of 448.9±45.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 225.3±28.7 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 58-46-8
Jingsj CID: J-28127-6
Molecular Formula: C₁₉H₂₇NO₃
Molecular Weight: 317.423 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	128-130ºC
Boiling Point	448.9±45.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	225.3±28.7 °C
Exact Mass	317.199097
PSA	38.77000
LogP	3.48
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.554

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Additional Information	[1]. Jankovic, J. and J. Beach, Long-term effects of tetrabenazine in hyperkinetic movement disorders. Neurology, 1997. 48(2): p. 358-62. [2]. Kenney, C., C. Hunter, and J. Jankovic, Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders. Mov Disord, 2007. 22(2): p. 193-7. [3]. Ondo, W.G., P.A. Hanna, and J. Jankovic, Tetrabenazine treatment for tardive dyskinesia: assessment by randomized videotape protocol. Am J Psychiatry, 1999. 156(8): p. 1279-81.

Additional Information

[1]. Jankovic, J. and J. Beach, Long-term effects of tetrabenazine in hyperkinetic movement disorders. Neurology, 1997. 48(2): p. 358-62. [2]. Kenney, C., C. Hunter, and J. Jankovic, Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders. Mov Disord, 2007. 22(2): p. 193-7. [3]. Ondo, W.G., P.A. Hanna, and J. Jankovic, Tetrabenazine treatment for tardive dyskinesia: assessment by randomized videotape protocol. Am J Psychiatry, 1999. 156(8): p. 1279-81.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Tetrabenazine?

The CAS number of Tetrabenazine is 58-46-8.

What are the molecular formula and molecular weight of Tetrabenazine?

Tetrabenazine has molecular formula C19H27NO3 and molecular weight 317.423 g/mol.

Is Tetrabenazine hazardous?

Tetrabenazine has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Tetrabenazine?

For Tetrabenazine, Upstream Products: 6,7-Dimethoxy-3,4-dihydroisoquinoline.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tetrabenazine (CAS 58-46-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28127-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.