Phaclofen

Also known as: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid, 3-Amino-2-(4-chlorophenyl)propylphosphonic acid, 3-Amino-2-(4-chlorophenyl)propanephosphonic acid, Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-, Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-, PHACLOFEN GABA(B) RECEPTOR ANTA

Phaclofen (CAS 114012-12-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C9H13ClNO3P and a molecular weight of 249.63100 g/mol. Key properties include a boiling point of 467.1ºC at 760 mmHg, a density of 1.432 g/cm3 and a flash point of 236.3ºC. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 114012-12-3
Jingsj CID: J-28092-2
Molecular Formula: C₉H₁₃ClNO₃P
Molecular Weight: 249.63100 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	467.1ºC at 760 mmHg
Density	1.432 g/cm3
Flash Point	236.3ºC
Exact Mass	249.03200
PSA	93.36000
LogP	2.26030

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	GABAB receptor[1]
Additional Information	[1]. Johnson CM, et al. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology. 2020;176:108214. [2]. Kerr DI, et al. Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 1987;405(1):150-154. [3]. Wüllner U, et al. Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats. Brain Res. 1989;496(1-2):341-344.

Target

GABAB receptor[1]

Additional Information

[1]. Johnson CM, et al. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology. 2020;176:108214. [2]. Kerr DI, et al. Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 1987;405(1):150-154. [3]. Wüllner U, et al. Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats. Brain Res. 1989;496(1-2):341-344.

Frequently Asked Questions

What is the CAS number of Phaclofen?

The CAS number of Phaclofen is 114012-12-3.

What are the molecular formula and molecular weight of Phaclofen?

Phaclofen has molecular formula C9H13ClNO3P and molecular weight 249.63100 g/mol.

Is Phaclofen hazardous?

Phaclofen has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Phaclofen?

For Phaclofen, Upstream Products: 1-(4-Chlorophenyl)-2-nitroethene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Phaclofen (CAS 114012-12-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28092-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.