Spiroxatrine

Also known as: R 5188, 8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one, Spiroxatrinum, MFCD00055134

Spiroxatrine (CAS 1054-88-2) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C22H25N3O3 and a molecular weight of 379.45 g/mol. Key properties include a boiling point of 602.8ºC at 760mmHg, a density of 1.32g/cm3 and a flash point of 318.4ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1054-88-2
Jingsj CID: J-28084-2
Molecular Formula: C₂₂H₂₅N₃O₃
Molecular Weight: 379.45 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	602.8ºC at 760mmHg
Density	1.32g/cm3
Flash Point	318.4ºC
Exact Mass	379.19000
PSA	54.04000
LogP	2.58660
Vapor Pressure	1.74E-14mmHg at 25°C
Refractive Index	1.665

Activity & Biological Data

Target	α2-adrenergic receptor 5-HT1A Receptor:3.94 nM (Ki) 5-HT1B/D Receptor:224000 nM (Ki) 5-HT2 Receptor:118.5 nM (Ki)
Additional Information	[1]. D L Nelson, et al. Spiroxatrine: a selective serotonin1A receptor antagonist. Eur J Pharmacol. 1986 May 13;124(1-2):207-8. [2]. Linda Cleary, et al. Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice. Br J Pharmacol. 2002 Jul;136(6):857-64. [3]. Z-Y Liu, et al. Involvement of 5-hydroxytryptamine(1A) receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation. Neuroscience. 2002;112(2):399-407. [4]. W J McBride, et al. Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. Pharmacol Biochem Behav. 1989 Oct;34(2):381-6.

Target

α2-adrenergic receptor 5-HT1A Receptor:3.94 nM (Ki) 5-HT1B/D Receptor:224000 nM (Ki) 5-HT2 Receptor:118.5 nM (Ki)

Additional Information

[1]. D L Nelson, et al. Spiroxatrine: a selective serotonin1A receptor antagonist. Eur J Pharmacol. 1986 May 13;124(1-2):207-8. [2]. Linda Cleary, et al. Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice. Br J Pharmacol. 2002 Jul;136(6):857-64. [3]. Z-Y Liu, et al. Involvement of 5-hydroxytryptamine(1A) receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation. Neuroscience. 2002;112(2):399-407. [4]. W J McBride, et al. Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. Pharmacol Biochem Behav. 1989 Oct;34(2):381-6.

Frequently Asked Questions

What is the CAS number of Spiroxatrine?

The CAS number of Spiroxatrine is 1054-88-2.

What are the molecular formula and molecular weight of Spiroxatrine?

Spiroxatrine has molecular formula C22H25N3O3 and molecular weight 379.45 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Spiroxatrine (CAS 1054-88-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-28084-2 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.