Valproic acid

Also known as: 2-Propylpentanoic acid, Dipropylacetic acid, 2-Propylvaleric acid, 2-n-Propylpentanoic acid, 2-n-Propylvaleric acid, Di-n-propylacetic acid, Depakene, Depakine, Convulex, Ergenyl, Mylproin, Valproate

Valproic acid (CAS 99-66-1) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H16O2 and a molecular weight of 144.211 g/mol. Key properties include a melting point of 120 - 130ºC, a boiling point of 220.0±0.0 °C at 760 mmHg, a density of 0.9±0.1 g/cm3 and a flash point of 111.1±0.0 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 99-66-1
Jingsj CID: J-27785-0
Molecular Formula: C₈H₁₆O₂
Molecular Weight: 144.211 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	120 - 130ºC
Boiling Point	220.0±0.0 °C at 760 mmHg
Density	0.9±0.1 g/cm3
Flash Point	111.1±0.0 °C
Exact Mass	144.115036
PSA	37.30000
LogP	2.72
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.435
Additional Property	slightly soluble

GHS Safety & Compliance

Irritant / Health HazardSignal word: Danger

H302 — Harmful if swallowed
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation
H360 — May damage fertility or the unborn child

Activity & Biological Data

Target	HDAC1:400 μM (IC50) HDAC:0.5-2 mM (IC50) HDAC2 Autophagy Mitophagy
Additional Information	[1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.

Target

HDAC1:400 μM (IC50) HDAC:0.5-2 mM (IC50) HDAC2 Autophagy Mitophagy

Additional Information

[1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.

Customs & Trade Information

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Valproic acid?

The CAS number of Valproic acid is 99-66-1.

What are the molecular formula and molecular weight of Valproic acid?

Valproic acid has molecular formula C8H16O2 and molecular weight 144.211 g/mol.

Is Valproic acid hazardous?

Valproic acid has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Valproic acid?

For Valproic acid, Upstream Products: 2,2-Dipropylmalonic acid, 2-Propylvaleronitrile, Ethyl acetoacetate; Downstream Products: ethyl 2-bromo-2-propylpentanoate, 2-Propyl-1-pentanol, Sodium 2-propylpentanoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Valproic acid (CAS 99-66-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-27785-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.