Osthole

Also known as: 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol, Ostol, Ostole, NSC 31868, AKOS 236-34, Cnidium lactone, Damiana extract, MFCD00076049

Osthole (CAS 484-12-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C15H16O3 and a molecular weight of 244.286 g/mol. Key properties include a melting point of 83-84°C, a boiling point of 396.7±42.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 167.6±22.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 484-12-8
Jingsj CID: J-2728-1
Molecular Formula: C₁₅H₁₆O₃
Molecular Weight: 244.286 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	83-84°C
Boiling Point	396.7±42.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	167.6±22.5 °C
Exact Mass	244.109940
PSA	39.44000
LogP	3.87
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.557

Activity & Biological Data

Target	Histamine H1 receptor[1]
Additional Information	[1]. Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology. [2]. Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25(6):1234-45. [3]. Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38(8):1120-1128.

Target

Histamine H1 receptor[1]

Additional Information

[1]. Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology. [2]. Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25(6):1234-45. [3]. Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38(8):1120-1128.

Customs & Trade Information

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Osthole?

The CAS number of Osthole is 484-12-8.

What are the molecular formula and molecular weight of Osthole?

Osthole has molecular formula C15H16O3 and molecular weight 244.286 g/mol.

What are the upstream and downstream products of Osthole?

For Osthole, Upstream Products: 3-Chloro-3-methyl-1-butene, 7-Hydroxycoumarin, (Ethoxycarbonylmethyl)triphenylphosphonium chloride; Downstream Products: Murraol, Osthenol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Osthole (CAS 484-12-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2728-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.