Tiagabine

Also known as: Gabitril, NNC 05-328, NO-05-0328, TGB, (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid, (R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid, 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, (3R)-, Tiagabin, Abbott-70569

Tiagabine (CAS 115103-54-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H25NO2S2 and a molecular weight of 375.55 g/mol. Key properties include a melting point of 192oC dec., a boiling point of 568ºC at 760 mmHg, a density of 1.208 g/cm3 and a flash point of 297.3ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 115103-54-3
Jingsj CID: J-26606-8
Molecular Formula: C₂₀H₂₅NO₂S₂
Molecular Weight: 375.55 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	192oC dec.
Boiling Point	568ºC at 760 mmHg
Density	1.208 g/cm3
Flash Point	297.3ºC
PSA	97.02000
LogP	5.78470
Vapor Pressure	9.71E-14mmHg at 25°C
Refractive Index	1.604
Storage Conditions	-20℃

Activity & Biological Data

Additional Information	[1]. Pollack, M.H., et al., The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J Clin Psychiatry, 2005. 66(11): p. 1401-8. [2]. Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40. [3]. Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70.

Additional Information

[1]. Pollack, M.H., et al., The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study. J Clin Psychiatry, 2005. 66(11): p. 1401-8. [2]. Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40. [3]. Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70.

Frequently Asked Questions

What is the CAS number of Tiagabine?

The CAS number of Tiagabine is 115103-54-3.

What are the molecular formula and molecular weight of Tiagabine?

Tiagabine has molecular formula C20H25NO2S2 and molecular weight 375.55 g/mol.

What are the upstream and downstream products of Tiagabine?

For Tiagabine, Upstream Products: Tiagabine ethyl ester, 2-Bromo-3-methylthiophene, 3-Methylthiophene-2-carboxaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tiagabine (CAS 115103-54-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-26606-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.