DL-Buthionine-(S,R)-sulfoximine

Also known as: Buthionine sulfoximine, BSO, 2-amino-4-(butylsulfonimidoyl)butanoic acid, S-butyl-DL-homocysteine (S,R)-sulfoximine, DL-Buthionine (S,R)-sulfoximine, DL-Buthionine sulfoximine, DL-Buthionine (R,S)-sulfoximine, DL-Buthionine-[S,R]-sulfoximine, EINECS 246-685-1, MFCD00070309

DL-Buthionine-(S,R)-sulfoximine (CAS 5072-26-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C8H18N2O3S and a molecular weight of 222.30500 g/mol. Key properties include a melting point of 215ºC (dec.)(lit.), a boiling point of 382.3ºC at 760 mmHg, a density of 1.29g/cm3 and a flash point of 185ºC. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 5072-26-4
Jingsj CID: J-25381-9
Molecular Formula: C₈H₁₈N₂O₃S
Molecular Weight: 222.30500 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	215ºC (dec.)(lit.)
Boiling Point	382.3ºC at 760 mmHg
Density	1.29g/cm3
Flash Point	185ºC
Exact Mass	222.10400
PSA	112.62000
LogP	2.30100
Refractive Index	1.537
Additional Property	H2O: 50 mg/mL, clear, colorless

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	glutamylcysteine synthetase[1]
Additional Information	[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60. [2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.

Target

glutamylcysteine synthetase[1]

Additional Information

[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60. [2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8.

Frequently Asked Questions

What is the CAS number of DL-Buthionine-(S,R)-sulfoximine?

The CAS number of DL-Buthionine-(S,R)-sulfoximine is 5072-26-4.

What are the molecular formula and molecular weight of DL-Buthionine-(S,R)-sulfoximine?

DL-Buthionine-(S,R)-sulfoximine has molecular formula C8H18N2O3S and molecular weight 222.30500 g/mol.

Is DL-Buthionine-(S,R)-sulfoximine hazardous?

DL-Buthionine-(S,R)-sulfoximine has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "DL-Buthionine-(S,R)-sulfoximine (CAS 5072-26-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-25381-9 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.