Cladribine

Also known as: 2-Chloro-2'-deoxyadenosine, 2-CdA, 2-CDA, 2-Chloro-9-(2-deoxy-β-D-arabinofuranosyl)adenine, Leustatin, Leustat, Litak, Movectro, CDA, 2-CL-DADO

Cladribine (CAS 4291-63-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C10H12ClN5O3 and a molecular weight of 285.687 g/mol. Key properties include a melting point of 181-185 °C(lit.), a boiling point of 547.6±60.0 °C at 760 mmHg, a density of 2.0±0.1 g/cm3 and a flash point of 285.0±32.9 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H311 — Toxic in contact with skin and H331 — Toxic if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 4291-63-8
Jingsj CID: J-23851-7
Molecular Formula: C₁₀H₁₂ClN₅O₃
Molecular Weight: 285.687 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	181-185 °C(lit.)
Boiling Point	547.6±60.0 °C at 760 mmHg
Density	2.0±0.1 g/cm3
Flash Point	285.0±32.9 °C
Exact Mass	285.062866
PSA	119.31000
LogP	0.02
Vapor Pressure	0.0±1.5 mmHg at 25°C
Refractive Index	1.871

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed
H311 — Toxic in contact with skin
H331 — Toxic if inhaled
H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Additional Information	[1]. Guchelaar, H.J., et al., Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model. Cancer Chemother Pharmacol, 1998. 42(1): p. 77-83. [2]. Bohm, A., et al., In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V. Exp Hematol, 2010. 38(9): p. 744-55. [3]. Klein, L.C., P.K. Yeung, and J.N. Berman, Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model. Biomarkers, 2009. 14(8): p. 554-9.

Additional Information

[1]. Guchelaar, H.J., et al., Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model. Cancer Chemother Pharmacol, 1998. 42(1): p. 77-83. [2]. Bohm, A., et al., In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V. Exp Hematol, 2010. 38(9): p. 744-55. [3]. Klein, L.C., P.K. Yeung, and J.N. Berman, Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model. Biomarkers, 2009. 14(8): p. 554-9.

Frequently Asked Questions

What is the CAS number of Cladribine?

The CAS number of Cladribine is 4291-63-8.

What are the molecular formula and molecular weight of Cladribine?

Cladribine has molecular formula C10H12ClN5O3 and molecular weight 285.687 g/mol.

Is Cladribine hazardous?

Cladribine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H311 — Toxic in contact with skin; H331 — Toxic if inhaled.

What are the upstream and downstream products of Cladribine?

For Cladribine, Upstream Products: 2,6-Dichloropurine; Downstream Products: 2'-Deoxyisoguanosine, 2'-Deoxyguanosine, 2-Chloroadenine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Cladribine (CAS 4291-63-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-23851-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.