Vilazodone

Also known as: 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide, CS-108, VIIBRYD, Vilazodone free base

Vilazodone (CAS 163521-12-8) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C26H27N5O2 and a molecular weight of 441.52 g/mol. Key properties include a melting point of 203-205ºC, a boiling point of 745.1ºC at 760 mmHg and a density of 1.34 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 163521-12-8
Jingsj CID: J-2379-0
Molecular Formula: C₂₆H₂₇N₅O₂
Molecular Weight: 441.52 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	203-205ºC
Boiling Point	745.1ºC at 760 mmHg
Density	1.34 g/cm3
PSA	102.29000
LogP	5.53478
Storage Conditions	-20°C

Activity & Biological Data

Additional Information	[1]. Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31. [2]. Citrome L. Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J C [3]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28(1):27-39. [4]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009 [5]. Thomas L. Schwartz Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor Therapeutic Advances in Psychopharmacology June 2011 vol. 1 no. 3 81-87

Additional Information

[1]. Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31. [2]. Citrome L. Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J C [3]. Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28(1):27-39. [4]. Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009 [5]. Thomas L. Schwartz Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor Therapeutic Advances in Psychopharmacology June 2011 vol. 1 no. 3 81-87

Frequently Asked Questions

What is the CAS number of Vilazodone?

The CAS number of Vilazodone is 163521-12-8.

What are the molecular formula and molecular weight of Vilazodone?

Vilazodone has molecular formula C26H27N5O2 and molecular weight 441.52 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Vilazodone (CAS 163521-12-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2379-0 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.