4-Hydroxytamoxifen

Also known as: Afimoxifene, (Z)-4-Hydroxytamoxifen, ICI 79,280, (Z)-4-(1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenyl-1-buten-1-yl)phenol, 4-{(1Z)-1-[{4-[2-(dimethylamino)ethoxy]phenyl}(phenyl)methylene]propyl}phenol, Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-, MFCD00278780

4-Hydroxytamoxifen (CAS 68047-06-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H29NO2 and a molecular weight of 387.514 g/mol. Key properties include a melting point of 105-107ºC, a boiling point of 514.4±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 264.9±30.1 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed, H312 — Harmful in contact with skin and H332 — Harmful if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 68047-06-3
Jingsj CID: J-23120-9
Molecular Formula: C₂₆H₂₉NO₂
Molecular Weight: 387.514 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	105-107ºC
Boiling Point	514.4±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	264.9±30.1 °C
Exact Mass	387.219818
PSA	32.70000
LogP	7.34
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.597
Storage Conditions	2-8°C
Stability	Stable. Store cool. Incompatible with strong oxidizing agents.
Additional Property	95% ethanol: 20 mg/mL

GHS Safety & Compliance

Irritant / Health HazardSignal word: Warning

H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled
H361 — Suspected of damaging fertility or the unborn child

Activity & Biological Data

Target	Estrogen receptor:3.3 nM (IC50) CRISPR/Cas9
Additional Information	[1]. Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75(2):305-16. [2]. Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. [3]. Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43.

Target

Estrogen receptor:3.3 nM (IC50) CRISPR/Cas9

Additional Information

[1]. Jordan VC, et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol. 1977 Nov;75(2):305-16. [2]. Davis KM, et al. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol. 2015 May;11(5):316-8. [3]. Kuo YM, et al. 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. J Neurochem. 2003 Dec;87(6):1436-43.

Frequently Asked Questions

What is the CAS number of 4-Hydroxytamoxifen?

The CAS number of 4-Hydroxytamoxifen is 68047-06-3.

What are the molecular formula and molecular weight of 4-Hydroxytamoxifen?

4-Hydroxytamoxifen has molecular formula C26H29NO2 and molecular weight 387.514 g/mol.

Is 4-Hydroxytamoxifen hazardous?

4-Hydroxytamoxifen has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H312 — Harmful in contact with skin; H332 — Harmful if inhaled.

What are the upstream and downstream products of 4-Hydroxytamoxifen?

For 4-Hydroxytamoxifen, Upstream Products: Dimethylamine, 4,4'-Dihydroxybenzophenone; Downstream Products: (E)-4-Hydroxytamoxifen.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Hydroxytamoxifen (CAS 68047-06-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-23120-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.