Maraviroc

Also known as: 4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide, 4,4-Difluoro-N-{(1S)-3-[(1R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide, 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-{(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide, CELSENTRI, Celsentri, CS-49, Cyclohexanecarboxamide, 4,4-difluoro-N-((1S)-3-((3-exo)-3-(3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)-, Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-, Cyclohexanecarboxamide, 4,4-difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]-, exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide, Maraviroc(Selzentry), Maraviroc(UK427857), maroviroc, UK-427857

Maraviroc (CAS 376348-65-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C29H41F2N5O and a molecular weight of 513.666 g/mol. Key properties include a melting point of 79-81ºC and a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 376348-65-1
Jingsj CID: J-2310-9
Molecular Formula: C₂₉H₄₁F₂N₅O
Molecular Weight: 513.666 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	79-81ºC
Density	1.3±0.1 g/cm3
Exact Mass	513.327942
PSA	63.05000
LogP	3.60
Refractive Index	1.628
Storage Conditions	Store at +4°C

Activity & Biological Data

Target	MIP-1α-CCR5:3.3 nM (IC50, in HEK-293 cell membrane) RANTES-CCR5:5.2 nM (IC50, in HEK-293 cell membrane) MIP-1β-CCR5:7.2 nM (IC50, in HEK-293 cell membrane) HIV-1 (Ba-L):1.1 nM (IC50, in PM-1 cells)
Additional Information	[1]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472 [2]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802. [3]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64. [4]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.

Target

MIP-1α-CCR5:3.3 nM (IC50, in HEK-293 cell membrane) RANTES-CCR5:5.2 nM (IC50, in HEK-293 cell membrane) MIP-1β-CCR5:7.2 nM (IC50, in HEK-293 cell membrane) HIV-1 (Ba-L):1.1 nM (IC50, in PM-1 cells)

Additional Information

[1]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472 [2]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802. [3]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64. [4]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.

Customs & Trade Information

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Maraviroc?

The CAS number of Maraviroc is 376348-65-1.

What are the molecular formula and molecular weight of Maraviroc?

Maraviroc has molecular formula C29H41F2N5O and molecular weight 513.666 g/mol.

What are the upstream and downstream products of Maraviroc?

For Maraviroc, Upstream Products: (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane, Cyclohexanecarbonyl chloride, 4,4-difluoro- (9CI), 4,4-Difluorocyclohexanecarboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Maraviroc (CAS 376348-65-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-2310-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.