Nipecotic acid
Also known as: DL-Nipecotic acid, 3-Piperidinecarboxylic acid, Piperidin-3-carboxylic acid, H-DL-Nip-OH, (±)-Piperidine-3-carboxylic acid, hexahydronicotinic acid, 3-PIPERIDINECARBOXYLIC ACID, DL-3-PIPERIDINECARBOXYLIC ACID, UNII:1U1QTN40SY, EINECS 207-873-9, MFCD00005992
Nipecotic acid (CAS 498-95-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C6H11NO2 and a molecular weight of 129.157 g/mol. Key properties include a melting point of 261ºC (dec.), a boiling point of 265.8±33.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 114.5±25.4 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 498-95-3
- Jingsj CID
- J-21607-9
- Molecular Formula
- C6H11NO2
- Molecular Weight
- 129.157 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 261ºC (dec.) |
|---|---|
| Boiling Point | 265.8±33.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Flash Point | 114.5±25.4 °C |
| Exact Mass | 129.078979 |
| PSA | 49.33000 |
| LogP | -0.04 |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| Refractive Index | 1.479 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | GABA Receptor[1] |
|---|---|
| Additional Information | [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. |
Customs & Trade Information
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of Nipecotic acid?
The CAS number of Nipecotic acid is 498-95-3.
What are the molecular formula and molecular weight of Nipecotic acid?
Nipecotic acid has molecular formula C6H11NO2 and molecular weight 129.157 g/mol.
Is Nipecotic acid hazardous?
Nipecotic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of Nipecotic acid?
For Nipecotic acid, Upstream Products: Nicotinic acid, Potassium carbonate, Ethyl nipecotate; Downstream Products: piperidin-3-yl(pyrrolidin-1-yl)methanone, 1-methylpiperidine-3-carboxylic acid, Ethyl piperidine-3-carboxylate hydrochloride.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Nipecotic acid (CAS 498-95-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-21607-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.