Verapamil

Also known as: 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile, (±)-Verapamil, dl-Verapamil, Calan, Isoptin, Vasolan, Dilacoran, CP 16533-1, D-365, NSC 272306, VPL, Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-

Verapamil (CAS 52-53-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C27H38N2O4 and a molecular weight of 454.602 g/mol. Key properties include a melting point of 25°C, a boiling point of 586.2±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 308.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 52-53-9
Jingsj CID: J-21220-4
Molecular Formula: C₂₇H₃₈N₂O₄
Molecular Weight: 454.602 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	25°C
Boiling Point	586.2±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	308.3±30.1 °C
Exact Mass	454.283173
PSA	63.95000
LogP	3.90
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.526

Activity & Biological Data

Target	Calcium channel[1] Permeability-glycoprotein (P-gp)[1] CYP3A4[1]
Additional Information	[1]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746. [2]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S. [3]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81. [4]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.

Target

Calcium channel[1] Permeability-glycoprotein (P-gp)[1] CYP3A4[1]

Additional Information

[1]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746. [2]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S. [3]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81. [4]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.

Frequently Asked Questions

What is the CAS number of Verapamil?

The CAS number of Verapamil is 52-53-9.

What are the molecular formula and molecular weight of Verapamil?

Verapamil has molecular formula C27H38N2O4 and molecular weight 454.602 g/mol.

What are the upstream and downstream products of Verapamil?

For Verapamil, Upstream Products: N-Methylhomoveratrylamine, 3-Methylbutanenitrile; Downstream Products: N-Methyl-4-(3,4-dimethoxyphenyl)-4-cyano-5-methylhexylamine, Dexverapamil.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Verapamil (CAS 52-53-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-21220-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.