8-Hydroxy-2-methylquinazolin-4(3H)-one
Also known as: NU1025, 8-Hydroxy-2-methyl-4(1H)-quinazolinone, 8-Hydroxy-2-methyl-4(3H)-quinazolinone, 8-Hydroxy-2-methyl-1H-quinazolin-4-one, MFCD00942555, NSC 696807
8-Hydroxy-2-methylquinazolin-4(3H)-one (CAS 90417-38-2) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C9H8N2O2 and a molecular weight of 176.172 g/mol. Key properties include a melting point of 253-258ºC, a boiling point of 345.4±44.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 162.7±28.4 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 90417-38-2
- Jingsj CID
- J-20392-9
- Molecular Formula
- C9H8N2O2
- Molecular Weight
- 176.172 g/mol
- Category
- Ketones
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 253-258ºC |
|---|---|
| Boiling Point | 345.4±44.0 °C at 760 mmHg |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 162.7±28.4 °C |
| Exact Mass | 176.058578 |
| PSA | 65.98000 |
| LogP | 0.35 |
| Appearance | solid | off-white |
| Vapor Pressure | 0.0±0.8 mmHg at 25°C |
| Refractive Index | 1.678 |
| Additional Property | DMSO: 35 mg/mL, soluble |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H319 — Causes serious eye irritation
Activity & Biological Data
| Target | IC50: 400 nM (PARP)[2] Ki: 48 nM (PARP)[3] |
|---|---|
| Additional Information | [1]. Kaundal RK, et al. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sci. 2006 Nov 10;79(24):2293-302. [2]. Bowman KJ, et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer. 1998 Nov;78(10):1269-77. [3]. Delaney CA, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6(7):2860-7. |
Customs & Trade Information
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Frequently Asked Questions
What is the CAS number of 8-Hydroxy-2-methylquinazolin-4(3H)-one?
The CAS number of 8-Hydroxy-2-methylquinazolin-4(3H)-one is 90417-38-2.
What are the molecular formula and molecular weight of 8-Hydroxy-2-methylquinazolin-4(3H)-one?
8-Hydroxy-2-methylquinazolin-4(3H)-one has molecular formula C9H8N2O2 and molecular weight 176.172 g/mol.
Is 8-Hydroxy-2-methylquinazolin-4(3H)-one hazardous?
8-Hydroxy-2-methylquinazolin-4(3H)-one has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H319 — Causes serious eye irritation.
What are the upstream and downstream products of 8-Hydroxy-2-methylquinazolin-4(3H)-one?
For 8-Hydroxy-2-methylquinazolin-4(3H)-one, Upstream Products: 8-Methoxy-2-methyl-3H-quinazolin-4-one, 8-Methoxyquinazolin-4-ol.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "8-Hydroxy-2-methylquinazolin-4(3H)-one (CAS 90417-38-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-20392-9 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.