Daphnetin

Also known as: 7,8-Dihydroxycoumarin, 7,8-Dihydroxy-2H-1-benzopyran-2-one, 7,8-Dihydroxy-2H-chromen-2-one, Daphnetol, Daphenetin

Daphnetin (CAS 486-35-1) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C9H6O4 and a molecular weight of 178.14 g/mol. Key properties include a melting point of 265-268°C (dec.), a boiling point of 430.4±45.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 184.5±22.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 486-35-1
Jingsj CID: J-20248-2
Molecular Formula: C₉H₆O₄
Molecular Weight: 178.14 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	265-268°C (dec.)
Boiling Point	430.4±45.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	184.5±22.2 °C
Exact Mass	178.026611
PSA	70.67000
LogP	0.77
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.689

Activity & Biological Data

Target	EGFR:7.67 μM (IC50) PKA:9.33 μM (IC50) PKC:25.01 μM (IC50)
Additional Information	[1]. Yang EB, et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260(3):682-5. [2]. Lv H, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52. [3]. Jiménez-Orozco FA, et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur J Pharmacol. 2011 Oct 1;668(1-2):35-41.

Target

EGFR:7.67 μM (IC50) PKA:9.33 μM (IC50) PKC:25.01 μM (IC50)

Additional Information

[1]. Yang EB, et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260(3):682-5. [2]. Lv H, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52. [3]. Jiménez-Orozco FA, et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur J Pharmacol. 2011 Oct 1;668(1-2):35-41.

Customs & Trade Information

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Daphnetin?

The CAS number of Daphnetin is 486-35-1.

What are the molecular formula and molecular weight of Daphnetin?

Daphnetin has molecular formula C9H6O4 and molecular weight 178.14 g/mol.

What are the upstream and downstream products of Daphnetin?

For Daphnetin, Upstream Products: DL-Malic acid, Pyrogallol, Propiolic acid; Downstream Products: 8-Hydroxy-7-methoxy-2H-chromen-2-one, 7,8-Dimethoxycoumarin, Hydrangetin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Daphnetin (CAS 486-35-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-20248-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.