Celiprolol

Also known as: Celectol, Selectol, REV 5320, RHC 5320A, 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea, N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethylurea, N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-N,N-diethylurea, (R,S)-Celiprolol

Celiprolol (CAS 56980-93-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H33N3O4 and a molecular weight of 379.494 g/mol. Key properties include a boiling point of 586.5±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 308.5±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 56980-93-9
Jingsj CID: J-20081-7
Molecular Formula: C₂₀H₃₃N₃O₄
Molecular Weight: 379.494 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	586.5±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	308.5±30.1 °C
Exact Mass	379.247101
PSA	90.90000
LogP	1.92
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.545

Activity & Biological Data

Target	Beta-adrenergic receptor:0.14-8.3 μM (Ki)
Additional Information	[1]. James J Nawarskas, et, al. Celiprolol: A Unique Selective Adrenoceptor Modulator. Cardiol Rev. Sep/Oct 2017; 25(5): 247-253. [2]. Toshio Hayashi, et al. beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes. Life Sci. 2007 Jan 16;80(6):592-9. [3]. Naohiko Kobayashi, et al. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stress. Hypertension. 2003 Nov;42(5):1004-13. [4]. R G Van Inwegen, et al. Effects of celiprolol (REV 5320), a new cardioselective beta-adrenoceptor antagonist, on in vitro adenylate cyclase, alpha- and beta-adrenergic receptor binding and lipolysis. Arch Int Pharmacodyn Ther. 1984 Nov;272(1):40-55. [5]. Yukio Kato, et al. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. [6]. J. Karlsson, et al. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br J Pharmacol. 1993 Nov; 110(3): 1009–1016.

Target

Beta-adrenergic receptor:0.14-8.3 μM (Ki)

Additional Information

[1]. James J Nawarskas, et, al. Celiprolol: A Unique Selective Adrenoceptor Modulator. Cardiol Rev. Sep/Oct 2017; 25(5): 247-253. [2]. Toshio Hayashi, et al. beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes. Life Sci. 2007 Jan 16;80(6):592-9. [3]. Naohiko Kobayashi, et al. Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 Via NF-kappaB induced by oxidative stress. Hypertension. 2003 Nov;42(5):1004-13. [4]. R G Van Inwegen, et al. Effects of celiprolol (REV 5320), a new cardioselective beta-adrenoceptor antagonist, on in vitro adenylate cyclase, alpha- and beta-adrenergic receptor binding and lipolysis. Arch Int Pharmacodyn Ther. 1984 Nov;272(1):40-55. [5]. Yukio Kato, et al. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. [6]. J. Karlsson, et al. Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein. Br J Pharmacol. 1993 Nov; 110(3): 1009–1016.

Frequently Asked Questions

What is the CAS number of Celiprolol?

The CAS number of Celiprolol is 56980-93-9.

What are the molecular formula and molecular weight of Celiprolol?

Celiprolol has molecular formula C20H33N3O4 and molecular weight 379.494 g/mol.

What are the upstream and downstream products of Celiprolol?

For Celiprolol, Upstream Products: 4-Nitrophenyl acetate, tert-Butylamine, 1-(2-Hydroxy-5-nitrophenyl)ethanone; Downstream Products: Celiprolol hydrochloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Celiprolol (CAS 56980-93-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-20081-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.