3,4,5-Trimethoxycinnamic acid

Also known as: (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid, 3-(3,4,5-trimethoxyphenyl)-2-propenoic acid, trans-3,4,5-Trimethoxycinnamic acid, 3,4,5-Trimethoxycinnamic acid, predominantly trans, 3-(3,4,5-trimethoxyphenyl)acrylic acid

3,4,5-Trimethoxycinnamic acid (CAS 90-50-6) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C12H14O5 and a molecular weight of 238.237 g/mol. Key properties include a melting point of 125-127 °C(lit.), a boiling point of 396.4±37.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 151.5±20.0 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 90-50-6
Jingsj CID: J-1993079-1
Molecular Formula: C₁₂H₁₄O₅
Molecular Weight: 238.237 g/mol
Category: Organic Acids
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Melting Point	125-127 °C(lit.)
Boiling Point	396.4±37.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	151.5±20.0 °C
Exact Mass	238.084122
PSA	64.99000
LogP	2.00
Vapor Pressure	0.0±1.0 mmHg at 25°C
Refractive Index	1.560

Activity & Biological Data

Target	γ-subunit of GABAA receptor[2]
Additional Information	[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Target

γ-subunit of GABAA receptor[2]

Additional Information

[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Customs & Trade Information

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 3,4,5-Trimethoxycinnamic acid?

The CAS number of 3,4,5-Trimethoxycinnamic acid is 90-50-6.

What are the molecular formula and molecular weight of 3,4,5-Trimethoxycinnamic acid?

3,4,5-Trimethoxycinnamic acid has molecular formula C12H14O5 and molecular weight 238.237 g/mol.

What are the upstream and downstream products of 3,4,5-Trimethoxycinnamic acid?

For 3,4,5-Trimethoxycinnamic acid, Downstream Products: 3,4,5-Trimethoxybenzoic acid, 3-(3,4,5-Trimethoxyphenyl)propanoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3,4,5-Trimethoxycinnamic acid (CAS 90-50-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1993079-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.