Chenodeoxycholic acid

Also known as: CDCA, Chenodiol, Chenodeoxycholate, 3alpha,7alpha-Dihydroxy-5beta-cholanic acid, Chenix, Fluibil, Kebilis, Ulmenide

Chenodeoxycholic acid (CAS 474-25-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C24H40O4 and a molecular weight of 392.572 g/mol. Key properties include a melting point of 165-167 °C(lit.), a boiling point of 547.1±25.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 298.8±19.7 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 474-25-9
Jingsj CID: J-1992829-1
Molecular Formula: C₂₄H₄₀O₄
Molecular Weight: 392.572 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	165-167 °C(lit.)
Boiling Point	547.1±25.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	298.8±19.7 °C
Exact Mass	392.292664
PSA	77.76000
LogP	4.66
Vapor Pressure	0.0±3.3 mmHg at 25°C
Refractive Index	1.543
Additional Property	PRACTICALLY INSOLUBLE

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation

Activity & Biological Data

Target	Human Endogenous Metabolite
Additional Information	[1]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92 [2]. Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710 [3]. Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11. [4]. Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56 [5]. Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab

Target

Human Endogenous Metabolite

Additional Information

[1]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92 [2]. Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710 [3]. Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11. [4]. Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56 [5]. Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab

Customs & Trade Information

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Frequently Asked Questions

What is the CAS number of Chenodeoxycholic acid?

The CAS number of Chenodeoxycholic acid is 474-25-9.

What are the molecular formula and molecular weight of Chenodeoxycholic acid?

Chenodeoxycholic acid has molecular formula C24H40O4 and molecular weight 392.572 g/mol.

Is Chenodeoxycholic acid hazardous?

Chenodeoxycholic acid has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Chenodeoxycholic acid?

For Chenodeoxycholic acid, Upstream Products: Chenodeoxycholic acid diacetate methyl ester, Sodium chenodeoxycholate, Lithocholic acid; Downstream Products: 7α-Hydroxy-4-cholesten-3-one, 3α-Hydroxy-7-oxo-5β-cholanic acid, Lithocholic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Chenodeoxycholic acid (CAS 474-25-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1992829-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.