Tolbutamide

Also known as: 1-butyl-3-(4-methylbenzenesulfonyl)urea, N-(butylcarbamoyl)-4-methylbenzenesulfonamide, Orinase, Rastinon, D-860, Diaben, Diabetol, Dolipol, Glyconon, Mobenol, Tolumid, Tolbusal, Willbutamide, Artosin, Butamide, Orezan, Pramidex

Tolbutamide (CAS 64-77-7) is a compound in the Solvents category listed in the Jingsj chemical database. It has the molecular formula C12H18N2O3S and a molecular weight of 270.348 g/mol. Key properties include a melting point of 128-130°C, a boiling point of 430.0±38.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 213.9±26.8 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 64-77-7
Jingsj CID: J-1991989-6
Molecular Formula: C₁₂H₁₈N₂O₃S
Molecular Weight: 270.348 g/mol
Category: Solvents
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	128-130°C
Boiling Point	430.0±38.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	213.9±26.8 °C
Exact Mass	270.103821
PSA	83.65000
LogP	2.93
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.557
Stability	Stable. Combustible.

Activity & Biological Data

Additional Information	[1]. Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4. [2]. Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.

Additional Information

[1]. Wray, H.L. and A.W. Harris, Adenosine 3', 5'-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4. [2]. Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.

Customs & Trade Information

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Frequently Asked Questions

What is the CAS number of Tolbutamide?

The CAS number of Tolbutamide is 64-77-7.

What are the molecular formula and molecular weight of Tolbutamide?

Tolbutamide has molecular formula C12H18N2O3S and molecular weight 270.348 g/mol.

What are the upstream and downstream products of Tolbutamide?

For Tolbutamide, Upstream Products: p-Toluenesulfonyl isocyanate, Butylamine, p-Toluenesulfonamide; Downstream Products: N-Butylurea, BI-P-TOLYL, 4-Hydroxytolbutamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tolbutamide (CAS 64-77-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1991989-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.