1,8-Cineole

Also known as: Eucalyptol, Cineole, Cajeputol, 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Epoxy-p-menthane, Terpan, Zineol, 2,2,4-Trimethyl-3-oxabicyclo[2.2.2]octane, 1,8-Cineol

1,8-Cineole (CAS 470-82-6) is a compound in the Alcohols category listed in the Jingsj chemical database. It has the molecular formula C10H18O and a molecular weight of 154.249 g/mol. Key properties include a melting point of 1.5ºC, a boiling point of 174.0±8.0 °C at 760 mmHg, a density of 0.9±0.1 g/cm3 and a flash point of 50.9±15.3 °C. It is classified under GHS with signal word Warning and hazard statements H226 — Flammable liquid and vapour. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 470-82-6
Jingsj CID: J-1991915-5
Molecular Formula: C₁₀H₁₈O
Molecular Weight: 154.249 g/mol
Category: Alcohols
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	1.5ºC
Boiling Point	174.0±8.0 °C at 760 mmHg
Density	0.9±0.1 g/cm3
Flash Point	50.9±15.3 °C
Exact Mass	154.135757
PSA	9.23000
LogP	2.82
Vapor Pressure	1.6±0.3 mmHg at 25°C
Refractive Index	1.461

GHS Safety & Compliance

FlammableSignal word: Warning

H226 — Flammable liquid and vapour

Activity & Biological Data

Target	5-HT3 Receptor IL-1β TNF-α potassium channel
Additional Information	[1]. Jarvis GE, et al. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling. J Pharmacol Exp Ther. 2016 Mar;356(3):549-62. [2]. Zeraatpisheh Z, et al. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels. Eur J Pharmacol. 2015 Oct 5;764:70-8. [3]. Khan A, et al. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease. Neurochem Res. 2014 Feb;39(2):344-52.[3] [4]. Caldas GF, et al. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats. Food Chem Toxicol. 2016 Nov;97:297-306.

Target

5-HT3 Receptor IL-1β TNF-α potassium channel

Additional Information

[1]. Jarvis GE, et al. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling. J Pharmacol Exp Ther. 2016 Mar;356(3):549-62. [2]. Zeraatpisheh Z, et al. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels. Eur J Pharmacol. 2015 Oct 5;764:70-8. [3]. Khan A, et al. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease. Neurochem Res. 2014 Feb;39(2):344-52.[3] [4]. Caldas GF, et al. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats. Food Chem Toxicol. 2016 Nov;97:297-306.

Frequently Asked Questions

What is the CAS number of 1,8-Cineole?

The CAS number of 1,8-Cineole is 470-82-6.

What are the molecular formula and molecular weight of 1,8-Cineole?

1,8-Cineole has molecular formula C10H18O and molecular weight 154.249 g/mol.

Is 1,8-Cineole hazardous?

1,8-Cineole has GHS signal word Warning and hazard statements H226 — Flammable liquid and vapour.

What are the upstream and downstream products of 1,8-Cineole?

For 1,8-Cineole, Upstream Products: Methylmagnesium iodide, alpha-Terpinene, alpha-Terpineol; Downstream Products: Menthofuran, 1,4-Cineole, m-Xylene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "1,8-Cineole (CAS 470-82-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1991915-5 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.