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5-Nitrothiophene-2-carboxaldehyde

Also known as: 5-Nitro-2-thiophenecarboxaldehyde, 5-Nitrothiophene-2-carbaldehyde, 2-Formyl-5-nitrothiophene, 5-Nitro-2-thienaldehyde, NSC 168226

5-Nitrothiophene-2-carboxaldehyde (CAS 4521-33-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C5H3NO3S and a molecular weight of 157.147 g/mol. Key properties include a melting point of 75-77 °C(lit.), a boiling point of 297.2±25.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 133.5±23.2 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
4521-33-9
Jingsj CID
J-1990982-1
Molecular Formula
C5H3NO3S
Molecular Weight
157.147 g/mol
Category
Pharma Intermediates
Last updated
8/21/2026

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Physicochemical Properties

Melting Point75-77 °C(lit.)
Boiling Point297.2±25.0 °C at 760 mmHg
Density1.5±0.1 g/cm3
Flash Point133.5±23.2 °C
Exact Mass156.983368
PSA91.13000
LogP1.15
Vapor Pressure0.0±0.6 mmHg at 25°C
Refractive Index1.663

GHS Safety & Compliance

IrritantSignal word: Warning
  • H315 — Causes skin irritation
  • H319 — Causes serious eye irritation
  • H335 — May cause respiratory irritation

Customs & Trade Information

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 5-Nitrothiophene-2-carboxaldehyde?

The CAS number of 5-Nitrothiophene-2-carboxaldehyde is 4521-33-9.

What are the molecular formula and molecular weight of 5-Nitrothiophene-2-carboxaldehyde?

5-Nitrothiophene-2-carboxaldehyde has molecular formula C5H3NO3S and molecular weight 157.147 g/mol.

Is 5-Nitrothiophene-2-carboxaldehyde hazardous?

5-Nitrothiophene-2-carboxaldehyde has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of 5-Nitrothiophene-2-carboxaldehyde?

For 5-Nitrothiophene-2-carboxaldehyde, Upstream Products: 2-Thiophenecarboxaldehyde, (5-Nitrothiophen-2-yl)methanol, (acetyloxy)(thiophen-2-yl)methyl acetate; Downstream Products: 5-Nitrothiophene-2-carbonyl chloride, 2-(Chloromethyl)-5-nitrothiophene, 5-Nitrothiophene-2-carboxylic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "5-Nitrothiophene-2-carboxaldehyde (CAS 4521-33-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1990982-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.