Ro 61-8048

Also known as: 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide, RO61-8048, Ro 61-8048, KMO Inhibitor I, Ro 61-8048, Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-

Ro 61-8048 (CAS 199666-03-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C17H15N3O6S2 and a molecular weight of 421.448 g/mol. Key properties include a boiling point of 627.4±65.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 333.3±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 199666-03-0
Jingsj CID: J-1987615-4
Molecular Formula: C₁₇H₁₅N₃O₆S₂
Molecular Weight: 421.448 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	627.4±65.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	333.3±34.3 °C
Exact Mass	421.040222
PSA	159.96000
LogP	3.38
Appearance	light yellow solid
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.641
Storage Conditions	-20℃

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H319 — Causes serious eye irritation

Activity & Biological Data

Additional Information	[1]. Rover S, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85. [2]. Cozzi A, et al. Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J C [3]. Hamann M, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

Additional Information

[1]. Rover S, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85. [2]. Cozzi A, et al. Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia. J C [3]. Hamann M, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

Frequently Asked Questions

What is the CAS number of Ro 61-8048?

The CAS number of Ro 61-8048 is 199666-03-0.

What are the molecular formula and molecular weight of Ro 61-8048?

Ro 61-8048 has molecular formula C17H15N3O6S2 and molecular weight 421.448 g/mol.

Is Ro 61-8048 hazardous?

Ro 61-8048 has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H319 — Causes serious eye irritation.

What are the upstream and downstream products of Ro 61-8048?

For Ro 61-8048, Upstream Products: 4-(3-Nitrophenyl)thiazol-2-ylamine, 3,4-dimethoxybenzenesulfonyl chloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ro 61-8048 (CAS 199666-03-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987615-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.