PB28 dihydrochloride
Also known as: PB-28, 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride, 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine dihydrochloride, Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-, PB28 dihydrochloride >=98% (HPLC), solid
PB28 dihydrochloride (CAS 172906-90-0) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C24H38N2O and a molecular weight of 370.58100 g/mol. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Nov 2, 2026.
- CAS No.
- 172906-90-0
- Jingsj CID
- J-1987601-8
- Molecular Formula
- C24H38N2O
- Molecular Weight
- 370.58100 g/mol
- Category
- Organic Acids
- Last updated
- 11/2/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Exact Mass | 442.25200 |
|---|---|
| PSA | 15.71000 |
| LogP | 6.32540 |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | Ki: 0.68 nM (σ2 receptor); 0.38 nM (σ1 receptor)[4] |
|---|---|
| Additional Information | [1]. Amalia Azzariti, et al. Cyclohexylpiperazine Derivative PB28, a sigma2 Agonist and sigma1 Antagonist Receptor, Inhibits Cell Growth, Modulates P-glycoprotein, and Synergizes With Anthracyclines in Breast Cancer. Mol Cancer Ther. 2006 Jul;5(7):1807-16. [2]. Maria Laura Pati, et al. Sigma-2 Receptor Agonist Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) Induce Cell Death via Mitochondrial Superoxide Production and Caspase Activation in Pancreatic Cancer. BMC Cancer. 2017 Jan 13;17(1):51. [3]. Nicola A Colabufo, et al. A New Method for Evaluating sigma(2) Ligand Activity in the Isolated Guinea-Pig Bladder. Naunyn Schmiedebergs Arch Pharmacol. 2003 Aug;368(2):106-12. [4]. Francesco Berardi, et al. Exploring the Importance of Piperazine N-atoms for sigma(2) Receptor Affinity and Activity in a Series of Analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28). J Med Chem. 2009 Dec 10;52(23):7817-28. [5]. David E Gordon, et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22;2020.03.22.002386. |
Frequently Asked Questions
What is the CAS number of PB28 dihydrochloride?
The CAS number of PB28 dihydrochloride is 172906-90-0.
What are the molecular formula and molecular weight of PB28 dihydrochloride?
PB28 dihydrochloride has molecular formula C24H38N2O and molecular weight 370.58100 g/mol.
Is PB28 dihydrochloride hazardous?
PB28 dihydrochloride has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of PB28 dihydrochloride?
For PB28 dihydrochloride, Upstream Products: 1-Cyclohexylpiperazine.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "PB28 dihydrochloride (CAS 172906-90-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987601-8 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.