NU7026

Also known as: 2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one, 2-Morpholin-4-ylbenzo[h]chromen-4-one, 2-(Morpholin-4-yl)-4H-benzo[h]chromen-4-one, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, 2-morpholino-4H-benzo[h]chromen-4-one, 4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-, LY 293646, LY293646, NU-7026, CS-595, DNA-PK Inhibitor II, DNA-Dependent Protein Kinase Inhibitor II

NU7026 (CAS 154447-35-5) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C17H15NO3 and a molecular weight of 281.306 g/mol. Key properties include a boiling point of 459.9±45.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 231.9±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 154447-35-5
Jingsj CID: J-1987584-4
Molecular Formula: C₁₇H₁₅NO₃
Molecular Weight: 281.306 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	459.9±45.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	231.9±28.7 °C
Exact Mass	281.105194
PSA	42.68000
LogP	3.29
Appearance	solid \| tan
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.673
Storage Conditions	2-8°C
Additional Property	DMSO: 3 mg/mL at 60 °C, soluble

Activity & Biological Data

Target	DNA-PK:0.23 μM (IC50) PI3K:13 μM (IC50)
Additional Information	[1]. Veuger SJ, et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 2003 Sep 15;63(18):6008-15. [2]. Amrein L, et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J [3]. Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005 Oct 31;93(9):1011-8.

Target

DNA-PK:0.23 μM (IC50) PI3K:13 μM (IC50)

Additional Information

[1]. Veuger SJ, et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 2003 Sep 15;63(18):6008-15. [2]. Amrein L, et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J [3]. Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005 Oct 31;93(9):1011-8.

Frequently Asked Questions

What is the CAS number of NU7026?

The CAS number of NU7026 is 154447-35-5.

What are the molecular formula and molecular weight of NU7026?

NU7026 has molecular formula C17H15NO3 and molecular weight 281.306 g/mol.

What are the upstream and downstream products of NU7026?

For NU7026, Upstream Products: N-Acetylmorpholine, Methyl 1-hydroxy-2-naphthoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "NU7026 (CAS 154447-35-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987584-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.